Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Cancer Predispositions > Pharmacology > Flashcards

Pharmacology Flashcards

(57 cards)

Start Studying
1
Q

Radiation Sensitizers

A

Doxorubicin Dactinomycin Gemcitibine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Gross total volume

A

volume occupied by tumor at diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clinical Target Volume

A

GTV + sires of suspected occult disease and involved adjacent lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Planning Target Volume

A

CTV + area getting dose accounting for variability (less for protons)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cranial irradtion for ALL

A

includes posterior half of eye and C2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Flank irradiation

A

includes whole vertebral bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

tumor spillage irradation

A

includes pelvis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Spinal irradiation

A

includes thecal sac to S3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Radiation dose for brain necrosis

A

60 Gy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Radiation dose for IQ defects

A

12 Gy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Radiation dose for GH deficiency

A

18 Gy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Radiation dose for precocious puberty

A

20 Gy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Radiation dose for TSH/FSH/ACTH deficiency

A

40 Gy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Doxorubicin extravisation

A

Cold compress, dexrazoxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Vinblastine extravisation

A

Warm compress, hyluronidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vincristine extravisation

A

warm compress, hyaluronidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Alkylating agents

A

temozolomide, melphalan, ifosfamide, cclophosphamide, thiotepa, carmustine, busulfan, cisplatin, carboplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Platinums

A

Cisplatin, Carboplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Platinum SE

A

Peripheral nueropathy, NV, Nephrotoxicity, myelosuppression, hepatoxicity, hypersenitivity, ototoxicity (cisplat>carbo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Cisplatin ototoxicity

A

High frequency sensioneural hearing loss >4,000 hz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Cyclophosphamide nephrotoxicity

A

water retention with hyponatremia from direct tubular damage not ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Ifosfamide nephrotoxicity

A

proximal tubular fanconi syndrome with glucosuria, phosphaturia, amino aciduria, riscketts, RTA distal tubular damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Mesna

Study These Flashcards
A

chelates acrolein

24
Q

Antidote for ifosfamide neurotoxicity

Study These Flashcards
A

methylene blue

25
Late effects for alkylators
Reproduction, pulmonary fibrosis for Busulfan nitrogen mustards, renal dysfunction, ototoxicity, secondary cancers
26
Antimetabolites
Methotrexate, mercaptopurine, thioguanine, fludarabine, cladribine, clofarabine, nelarabine, cytarabine, gemcitabine, flurorouracil
27
Antimetabolite SE
myelosuppression, hepatotoxicity, mucositis, NV, neurotoxicity, rash, pulmonary toxicity HD MTX nephrotoxic Radiation Recall gemcitabine
28
Methotrexate neurotoxicity
10-14 day onset resolves 1-7 days 10-50% recur??? can cause chronic encephalopathy
29
Cytarabine neurotoxicity
acute cerebellar syndrome ataxia nystagmus dysmetria dysarthria 3-8 day onset resolves 1 wk 30% have residual effect
30
Nelarabine neurotoxicity
solmnolence, seizures Guillan Barre like syndrome gradually reversible
31
Fludarabine neurotoxicity
progressive leukoencephalopathy can be fatal delayed onset demyelination
32
HD methotrexate nephrotoxicity
High output renal failure antidote glucarpidase
33
Glucarpidase
cleaves circulating Mtx into DAMPA and glutamic acid
34
Mercaptopurine interaction
Allopurinol
35
Methotrexate interaction
Aspirin, penicillin, NSAIDs, ciprofloxacin, sulfas, L-Asp (give 24h after MTX)
36
Topoisomerase
I Topotecan/irinotecan II Doxorubicin, daunorubicin, idarubicin, etoposide, mitoxantrone, dactinomycin
37
Topoisomerase SE
NV myelosuppression, mucositis, diarrhea, anthrcyclines - cardiac, hepatic, vesicants, radiation sensitizers (doxo, dactino, dauno, ida) etop infusion reaction
38
Inrinotecan diarrhea
prodrug metablized to SN-38 Hyperacture <8H - atropine Acute >8 hours - octreotide prophy cefixime
39
Tubulin binding (microtubule inhibitors)
Vinca alkyloids paclitaxel docetaxel erlibulin
40
Microtubule inhibitor SE
Myelosupression except VCR Neuropathy SIADH Vinblastine - mucositis Vesicants (warm compress)
41
Steroids
Dex not bound to transcortin so crosses BBB
42
Steroid SE
centipedal obesity growth failure immunosuppression myopathy avascular necrosis gastric ulcers pancreatitis diabetes psychiatric disorders hypertension impaired wound healing
43
Asparginase
leukemic blasts are deficient in aspargine synthase Peg-asparginase T1/2 5-7 days Erwinea T1/2 10-15 hours Calaspargase T1/2 16 days
44
Asparginase SE
Hypersensitivity Coagulopathy pancreatitis hepatic toxicity neurotoxicity
45
Bleomycin
Chlates metals that bine DNA and produce double stranded breaks
46
Bleomycin SE
interstitial pneumonitis hyperpigmentation hypersensitivity raynaud
47
Arsenic Trioxide
apoptosis SE prolonged QTc leukocytosis, APL differentiation Hepatotoxicity dermatitis low mag, ca, hyperglycemia
48
ATRA
differentiation syndrome chelitis headache, psuedotumor cerebri bone and joint pain hypertriglyceridemia venous thrombosis
49
13-cis retinoic acid
skin sensitivity headache hypertryglyceridemia hypercalcemia epiphyseal changes pseudotumor cerebri visual changes psychiatric disorders
50
BCR-ABL inhibitors TKIs
Imatinib - NV fatigue dh hepatoxicity hemorrhagic pleural effusions Dasatinib dh headache hypokalemia poor bone growth pleural and pericardial effusion nolatinib same with arthralgias, constipation, nasopharyngitis, pyrexia
51
Axitinib, Pazopanib
VEGF PDGF C-Kit RCC
52
Sorafinib
VEGF PDGF c-KIT HCC AML FLT3 RCC
53
ALK inhibitors
Lorlatinib Large cell anaplasctic lymphoma NBL
54
NTRK inihibitors
Larotrectinib
55
DNA methylation inihibitors
Azacitidine and decitabine activates tumor suppressor genes silences by hypermethylation
56
Gemtuzumab
Anti CD33
57
Brentuxumab
Anti CD30

Cancer Predispositions (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions