Pharmacology

Question 1

What’s MOA for ACyclovir

Answer 1

✓Inhibits herpes virus DNA polymerase competitively
✓incorporated in viral DNA and stops lengthening of DNA strand

Question 2

………. Used to prevent and treat Cytomegalovirus (CMV) diseases.

Answer 2

Cidofovir

Question 3

Does not require activation by viral (or cellular) kinases.

Answer 3

Foscarnet

Question 4

Used in Acyclovir-‐resistant HSV and herpes zoster infections.

Answer 4

Foscarnet

Question 5

Inhibits influenza virus Neuraminidase enzyme

Answer 5

Oseltamivir (Tamiflu®)
Zanamivir

Question 6

First line drug for chronic hepatitis B

Answer 6

Lamivudine

Question 7

inhibitor of both (HBV) DNA polymerase and
(HIV) reverse transcriptase

Answer 7

Lamivudine

Question 8

(Flu-‐like syndrome ) side effect for which drug

Answer 8

Interferons alpha

Question 9

Is not active orally

Answer 9

Interferons

Question 10

What is the active form ( phosphorylated ) of lamivudine ?

Answer 10

Nucleoside revers transcriptase inhibitors( NRTI)

Question 11

Used to Management of respiratory syncytial virus

Answer 11

Ribavirin

Question 12

Adjunct to alpha interferons to treat HCV

Answer 12

Ribavirin

Question 13

Is a nucleotide analog that prevents replication of HBV.

Answer 13

Adefovir

Question 14

HIV protease inhibitors

Answer 14

Lopinavir
Ritonavir

Question 15

Lopinavir and Ritonavir are….

Question 16

Reversible inhibitors of the HIV aspartyl protease

Answer 16

Lopinavir
Ritonavir

Question 17

Raltegravir is

Answer 17

HIV integrase inhibitor

Question 18

What is the side effect of raltegravir

Answer 18

Myopathy

Question 19

It is Entry inhibitor drug that Binds to HIV-‐1 envelope transmembrane glycoprotein(gp41)

Answer 19

Enfuviritide

Question 20

It is Entry inhibitordrug that Targets the host cell chemokine co- receptor (CCR5) and block the attchment

Answer 20

Maraviroc

Question 21

Polymerase inhibitors

Answer 21

Acyclovir
Cidofovir

Question 22

is the only agent that prevents relapses of the

Answer 22

Primaquine

Question 23

Effective agent for prophylaxis from all plasmodia

Answer 23

Mefloquin

Question 24

Used with artemisinin to treat multidrug resistant forms of P. Falciparum

Answer 24

Mefloquin