PHARMACOLOGY

Question 1

Prevents the creation of new clots

Answer 1

Anti-coagulants

Question 2

Classic Hemophilia: clotting factor missing / deficient

Answer 2

Factor 8

Question 3

Christmas Hemophilia: clotting factor missing / deficient

Answer 3

Factor 9

Question 4

Rosenthal Syndrome: clotting factor missing / deficient

Answer 4

Factor 11

Question 5

Most common hereditary blood-clotting disorder

Answer 5

Von-Willebrand Disease

Question 6

Antidote: Heparin

Answer 6

Protamine Sulfate

Question 7

Antidote: Warfarin

Answer 7

Vitamin K

Question 8

Fast onset anti-coagulant

Answer 8

Heparin

Question 9

Slow onset anti-coagulant

Answer 9

Warfarin

Question 10

Emergency anti-coagulant

Answer 10

Heparin

Question 11

Maintenance anti-coagulant

Answer 11

Warfarin

Question 12

Half-life: Warfarin

Answer 12

42 hrs

Question 13

Half-life: Heparin

Answer 13

1-2 hrs

Question 14

What to WOF in Heparin SQ

Answer 14

Hematoma, ecchymosis, inflammation

Question 15

What to assess for in anti-coagulant administration

Answer 15

Signs of bleeding and hemorrhage

Question 16

How often do you monitor platelet count throughout anti-coagulant therapy?

Answer 16

2-3 days

Question 17

What is contraindicated while on anticoagulant therapy?

Answer 17

Aspirin and NSAIDs

Question 18

What route to avoid in administering other meds while on anti-coagulant therapy

Answer 18

IM

Question 19

(N) PTT: Heparin

Answer 19

60-70 secs

Question 20

PTT: >70 secs indicates

Answer 20

Bleeding

Question 21

PTT: <60 secs indicates

Answer 21

Thrombosis

Question 22

(N) PT: Warfarin

Answer 22

9-12 secs

Question 23

Therapeutic Range: Warfarin

Answer 23

2-3 IU

Question 24

(N) APTT: Heparin

Answer 24

20-36 secs

Question 25

Warfarin is contraindicated in?

Answer 25

Pregnancy

Question 26

What to WOF in Heparin

Answer 26

HIT (Heparin-Induced Thrombocytopenia)

Question 27

Examples of LMWH (Low-molecular weight Heparin)

Answer 27

Enoxaparin Dalteparin

Question 28

Example of DTI (Direct Thrombin Inhibitor)

Answer 28

Dabigatran

Question 29

Warfarin: Factor Xa Inhibitors:

Answer 29

Rivaroxaban Apixaban

Question 30

Heparin: Factor Xa Inhibitor:

Answer 30

Fondaparinux

Question 31

APTT: w/o Heparin

Answer 31

25 secs

Question 32

APTT: w/ Heparin

Answer 32

60 secs

Question 33

Heparin: Onset

Answer 33

20 min

Question 34

Heparin: Peak

Answer 34

4 hrs

Question 35

Heparin SQ: Onset | Peak | Duration

Answer 35

20-60 min 2 hrs 8-12 hrs

Question 36

Heparin IV: Onset | Peak | Duration

Answer 36

Immediate 5-10 min 2-6 hrs

Question 37

Warfarin PO: Onset | Peak | Duration

Answer 37

36-72 hrs 5-7 days 2-5 days

Question 38

Warfarin: Onset

Answer 38

2-5 days

Question 39

Heparin: Monitor / compute for control time

Answer 39

• Get baseline APTT / PTT / PT • Multiply baseline 1.5 & 2.0

Question 40

Warfarin: Monitor / compute for control time

Answer 40

• Get baseline APTT/ PTT / PT • Multiply baseline 1.25 & 2.25

Question 41

Heparin A/E: GI

Answer 41

Drug- induded Hepatitis

Question 42

Heparin A/E: Derma

Answer 42

Alopecia (long term use) | Rashes | Urticaria

Question 43

Heparin A/E: Hema

Answer 43

Bleeding | HIT | Anemia

Question 44

Heparin A/E: Musculo

Answer 44

Osteoporosis (long-term use)

Question 45

Warfarin A/E: Derma

Answer 45

Dermal necrosis

Question 46

Warfarin A/E: GI

Answer 46

Cramps | Nausea

Question 47

Warfarin A/E: GU

Answer 47

Calciphylaxis

Question 48

Warfarin A/E: Hema

Answer 48

Bleeding

Question 49

Dissolve / Destory Clot: Clot buster

Answer 49

Thrombolytics

Question 50

Converts plasminogen to plasmin

Answer 50

Alteplase

Question 51

Given to people with ischemic stroke

Answer 51

tPA

Question 52

Antidote: Thrombolytics

Answer 52

Aminocaproic Acid (Amicar)

Question 53

Half-life: Alteplase

Answer 53

35 mins

Question 54

Half-life: Streptokinase

Answer 54

Initially 18 min, then 83 min

Question 55

Half-life: Reteplase

Answer 55

13-16 min

Question 56

Half-life: Tenecteplase

Answer 56

Initial phase: 20-24 min Terminal phase: 90-130