Pharmacology

Question 1

What is the antidote to unfractioned heparin

Answer 1

protamine IV

Question 2

mechanism of action of adalimumab

Answer 2

TNF alpha ihibitor

Question 3

Mechanism of action of chloramphenicol

Answer 3

inhibits intracellular protein sythesis, 50s ribosome unit

Question 4

Mechanism of action of NAC

Answer 4

Increases glutathione production in the liver by providing cysteine
reduction of the circulation of toxic metabolites

Question 5

side effects of amiodarone

Answer 5

photosensitive rash

Question 6

mechanism of action of dornase alpha

Answer 6

endonucleatic cleavage of extracellular DNA

Question 7

mechanism of action of aminophylline

Answer 7

phosphodiesterase type-III antagonist

Question 8

mechanism of Benzodiazepines

Answer 8

positive allosteric modulator of GABA- alpha receptor
increase potency of GABA

Question 9

mechanism of levetiracetam

Answer 9

Binds to SV2A which regulates release of neurotransmitters into vesicles

Question 10

mechanism of ondansetron

Answer 10

blocks serotonin 5-HT3 receptors

Question 11

mechanism of chlorphenamine

Answer 11

H-1 receptor blocker

Question 12

mechanism of action of domperidone

Answer 12

dopamine receptor antagonist

Question 13

what do you need to monitor when a patient is on IV Quinine

Answer 13

BM
can cause hypoglycaemia

Question 14

mechanism of action of methylphenidate

Answer 14

inhibition of dopamine reuptake in the basal ganglia
sodium dependent dopamine transporter inhibitor

Question 15

mechanism of action of caffeine citrate

Answer 15

blocks adenosine receptors

Question 16

mechanism of tocilizumab

Answer 16

IL-6 receptor
rheumatology practice

Question 17

mechanism of flucloxacillin

Answer 17

inhibit bacterial wall synthesis

Question 18

mechanism of gentamicin

Answer 18

binding of 30S ribosome to inhibit bacterial synthesis

Question 19

mechainsm of adenosine

Answer 19

A1-adenosine receptor agonist

Question 20

mechanism of methylphenidate

Answer 20

increase dopamine activity

Question 21

mechanism of action of carbamazepine

Answer 21

blockage of voltage gated sodium channels

Question 22

mechanism of action of phenylephrine

Answer 22

Alpha 1 adrenoceptors agonist

Question 23

mechanism of hyoscine patch

Answer 23

m1 muscarinic antagonist/ competitive inhibition of muscarinic acetylcholine receptors

Question 24

mechanism of action of furosemide

Answer 24

decreased resabsorption of sodium

Question 25

mechanism of action of alendronic acid

Answer 25

inhibits osteoclastic activity

Question 26

mechanism of action of milrinone

Answer 26

competitive inhibitor of phosphodiesterase III

Question 27

mechanism of morphine

Answer 27

adenylyl cyclase inhibitor binds to opioid receptions which are coupled with G protein receptors which inhibits adenylyl cyclase.

Question 28

mechanism of action of ipratropium bromide

Answer 28

cholinergic receptor blocker decreased contraction of smooth muscles in lungs by blocking muscarinic cholinergic receptors

Question 29

mechanism of phenylephrine (mydriatic eye drops) and side effect

Answer 29

alpha adrenoceptor agonist SE: severe HTN reaction

Question 30

mechanism of vigabatrin

Answer 30

irreversible inhibition of GABA transaminase

Question 31

mechanism of phenytoin

Answer 31

inhibits sodium channels sodium channel blocker

Question 32

mechanism of insulin

Answer 32

binds to insulin receptors stimulating release of ATP GLUT4 receptors from intracellular vesicles to the cell membrane, which transport glucose via diffusion across the cell membrane

Question 33

mechanism of atomoxetine

Answer 33

selective norepinephrine re-uptake inhibitor

Question 34

mechanism of omeprazole

Answer 34

H+/K+ adenosine triphosphatase pump inhibitor

Question 35

mechanism of montelukast

Answer 35

blocks leukotriene receptors. inhibition of eosinophil recruitment

Question 36

mechanism of metformin

Answer 36

reduces hepatic glucose production by inhibiting hepatic gluconeogenesis

Question 37

mechanism of ethosuximide

Answer 37

blocks T type voltage gated calcium channels

Question 38

mechanism cyclopentolate

Answer 38

muscarinic acetylcholine M1 receptor antagonist

Question 39

method used in live attenuated vaccines

Answer 39

passage through foreign host

Question 40

mechanism of azithromycin

Answer 40

binds to 23s recombinant RNA of the bacteria 50s ribosome subunit to inhibit bacterial synthesis

Question 41

mechanism of allopurinol

Answer 41

inhibits xanthine oxidase directly and through its active metabolite

Question 42

mechanism of adrenaline

Answer 42

acts on alpha-1 receptor to increase vascular resistance

Question 43

mechanism of atenolol

Answer 43

selective beta-1 adrenoreceptor antagonist

Question 44

mechanism of lamatrogine

Answer 44

inactivates sodium channels