Pharmacology Flashcards
(27 cards)
PK
What the body does to the drug (absorption, metabolism, elimination)
PD
effect of drug on target
Affinity
capacity of the drug to bind to the receptor
Efficacy
The ability of drug to do its job
Ec50
The concentration needed for 50% maximal response
Therapeutic index
TD50/ED50
A (higher/lower) therapeutic index means a safer drug
higher
Potency
Concentration of a drug needed for effect (compared to other drugs)
Tachyphylaxis
rapid decrease in response after a few doses
absorption is proportional to (3) and inversely proportional to (1)
-Proportional to: surface area, lipophilicity, drug gradient
-Inversely proportional to membrane thickness
Phase 1 metabolism
oxidation, deamination, hydrolysis, reduction by CYP450, 3A26, 3A12
Phase 2 metabolism
conjugation via UTG, NAC, alcohol dehydrogenase
Phase 1 inducers (3)
phenobarbital, rifampin, greiesofulvin
Phase 1 inhibitors (5)
Chloramphenicol, fluoroquinolones, ketoconazole, erythromycin, azithromycin
Weak acids are trapped in (alkaline/acidic) urine
alkaline
Increasing volume of distribution (increase/ decrease) T1/2
increases
lipophilic drugs have a (longer/shorter) t1/2
longer
0 order elimination
constant amount eliminated / time
1st order elimination
volume of blood cleared / time
60/90 rule
bacteria treated with a drug it is sensitive to on C/S will respond 90% of the time
Bacteria treated with a drug it is not sensitive to on C/S will respond 60% of the time
Methadone MOA
pure mu agonist, weak NMDA antagonist
Fentanyl MOA
pure mu agonist
Buprenorphine MOA
partial mu agonist
tramadol MOA
Mu agonist, SNRI
