Pharmacology Flashcards
(35 cards)
What is the ICS definition for overactive bladder?
urinary urgency, with or without urgency urinary incontinence
Can a patient have overactive bladder without DO?
Yes
What receptor in the bladder is most important for detrusor contraction?
M3
Which receptor in the bladder is predominant in number?
M2
What type of receptor are Muscarinic ones?
cholinergic
Name 2 types of adrenergic receptors
alpha and beta
Name 2 non-surgical of phamacological treatments for oab?
lifestyle intervention (reduce caffeine + weight loss), PFMT,
Name 2 surgical treatments for oab
sacral neuromodulation, botulnim toxin type A
What receptors do anticholinergic drugs work on?
Muscarinic
What are the 3 subytpes of anticholinergic drugs?
- non-selective
- primary M3-selective
- M3-selective
What is advanatge of M3 selective
- less sever dry mouth, no effect on heart rate + fewer cognitive effects
Oxybutynin - 4 facts
- anticholinergic
- primarily M3 selective
-immediate release - crosses blood-brain barrier
Tropsium Chloride - 3 facts
- anticholinergic
-not cross blood brain barrier
-M2 receptor affinity so cardiovascular effect - non-selective
Tolterodine - 2 facts
- Non-selective
- fewer side effects than oxybutinin + similar efficacy (OPERA trial)
Solifenacin - 3 facts
- long acting
- no CNS or cardiovascular effects
- primarily M3 selective
Darifenacin - 2 fatcs
- greatest M3 affinity (M3 selective)
- No CNS or cardiovascular effects
What receptors does Mirabegron act on
B3 adrenoreceptor
Two pharmacological treatments for BPH
- alpha adrenoreceptor antagonists
- 5 alpha reductase inhibitors
What is mechanism of action of alpha adrenoreceptors antagonists
relaxation
what is mechanism of 5 alpha reductase inhibitor
reduce prostate growth
Finasteride
-5ARI (blocks type II)
Dutasteride
5ARI (blocks types I and II)
Tamsulosin
a1aR antagonist
