Pharmacology

Question 1

MOA of Adenosine

Answer 1

Class V antiarrhythmic, depresses sinus node activity and slows conduction through the AV node, also peripheral and coronary vasodilation

Question 2

MOA of Ligocaine

Answer 2

Class I antiarrhythmic, blocks sodium channels in the conduction to raise depolarisation threshold and increase automacity

Question 3

MOA of Digoxin

Answer 3

Class V antiarrhythmic, inhibits Na+/K+ ATPase pump, positive inotrophic, decrease rate

Question 4

MOA of Amiodarone

Answer 4

Class III antiarrhythmic, K+ channel blocker, prolongs myocardial cell AP duration and refractory period. Also decreases sinus node activity and slows AV node conduction

Question 5

MOA of Warfarin

Answer 5

Inhibits Vit K reductase, resulting in depletion of reduced Vit K, limiting production of Vit K dependent factors II, VII, IX, X

Question 6

MOA of Heparin

Answer 6

Binds and accelerates activity of Antithrombin III, inhibiting coagulation factors Xa and IIa (thrombin)

Question 7

Adverse effects of Beta blockers

Answer 7

Bradycardia, exacerbate Raynaud’s phenomenon, heart block

Question 8

MOA of sotalol

Answer 8

K+ channel blocker and beta blocker. Slow heart rate and decreased AV node conduction