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Flashcards in Pharmacology Deck (44):
1

Alpha 1

1. Vasoconstriction
2. Mydriasis
3. Intestinal and bladder sphincter contraction

2

Alpha 2

Decreases sympathetic tone: (-) feedback
Decrease Insulin release

3

Beta 1

Inc. HR
Inc. Contractility
Inc. lipolysis
Inc. renin release

4

Beta 2

Bronchodilation
Vasodilation (reflex tachycardia, cont)

Inc. insulin release
Dec. uterine tone (tocolytic)
Inc. aqueous humor production

5

M1

CNS
Enteric NS

6

M2

Dec. HR
Dec. Contractilty

7

M3

Inc. Gland secretion
Inc. gut peristalsis
Inc. bladder contraction
Bronchoconstriction
Miosis
Accomodation

Increase Insulin

8

D1

Kidneys - relaxes vascular smooth muscle

9

D2

CNS - modulates transmitter release

10

H1

Allergy Sx:

Inc. Nasal and Bronchial mucus production
Inc. Vascular permeability
Inc. contraction bronchioles
Pruritis, Pain

11

H2

Inc. Gastric Acid Secretion

12

V1

vasoconstriction

13

V2

kidney - Inc. H20 permeability and reabsorption in collecting tubules (V2 for 2 kidneys)

14

G protein coupler receptors

Gq: HAV1 M1&M3
Gi: MAD2
GS: everything else

15

Hemicholinium

Inhibit Choline-Na transporter

16

Vesamicol

Inhibit Ach packaging into vesicles

17

Botulinum

Inhibit exocytosis of Ach

18

Black Widow Spider Toxin

Stimulate exocytosis of Ach

19

Metyrosine

Inhibit Tyrosine hydroxylase: Tyr --> L-DOPA

20

Reserpine

Inhibit NE packaging into vesicles

21

Drugs that stimulate NE release

Amphetamine
Tyramine
Ephedrine

22

Drugs that inhibit NE Reuptake

Cocaine
TCA

23

Drugs that inhibit NE exocytosis

Bretylium
Guanethidine

24

Metabolism of NE

COMT
MAO

Dopa -> HVA
NE -> VMA
Epi -> Metanephrine

25

Direct Ach Agonist: Cholinomimetic agents (4)

Bethanechol - postop ileus, urinary retention

Carbachol- Glaucoma

Methacholine- asthma challenge

Pilocarpine - stimulator of sweat, tears, saliva. "you cry, drool, and sweat on your PILOws"

26

Neostigmine

Anticholinesterase

- postop ileus
- urinary retention
- MG

Neo CNS = NO CNS penetration

27

Pyridostigmine

MG

28

Physostigmine

Atropine OD

Does cross BBB.

29

Donepezil, Rivastigmine, Galantamine

Alzheimer's disease

30

Edrophonium

Tensilon test

31

Exacerbation of what diseases may occur with cholinomimetic agents

COPD, asthma, peptic ulcers

32

Atropine, Homatropine, Tropicamide

Muscarinic Antagonist

Mydriasis and cycloplegia of eye

33

Benztropine

Muscarinic Antagonist

Parkinson's: Park my Benz

34

Scopolamine

Muscarinic Antagonist

Dec. oral secretions
Motion sickness

35

Ipratropium, Tiotropium

Muscarinic Antagonist

COPD, asthma

36

Drugs that decrease overactive bladder/urge incontinence

"On The Darn Toilet"
Muscarinic Antagonist

Oxybutynin
Tolterodine, Trospium
Darifenacin, Solifenacin

37

Glycopyrrolate

Muscarinic Antagonist

38

Epinephrine

All 4 sympathomimetics
Beta > alpha

Anaphylaxis

39

NE

alpha 1 > alpha 2 > beta1

Hypotension

40

Isoproterenol

beta 1 = beta 2

41

Dopamine

D1 = D2 > beta > alpha
low doses > med doses > high doses

Heart failure, shock

42

Dobutamine

beta 1 > beta 2 > alpha

Heart failure
Cardiac stress testing

43

Phenylephrine

alpha 1 > alpha 2

Rhinitis

44

Albuterol, Salmeterol, Terbutaline

beta 2 > beta 1

Acute asthma