Pharmacology Flashcards

(84 cards)

1
Q

Define “drugs”

A

Foreign substances in the body

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2
Q

Define “medications”

A

Drugs that are used to treat and prevent disease.

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3
Q

Define “pharmacology”

A

The study of drugs and their effects on the body

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4
Q

What are the four main sources of drugs?

A

Plants, Minerals, Animals and Laboratory.

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5
Q

What is the United States Pharmacopeia (USP)?

A

A nongovernmental official public standards setting authority over prescription and over the counter drugs.

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6
Q

Define “pharmacodynamics”

A

How medications interact with the body to produce it’s effects

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7
Q

Define “pharmacokinetics”

A

How medications are transported into and out of the body

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8
Q

What are the four types of drug names?

A

Official, Chemical, Generic and Trade

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9
Q

What did the Pure Food and Drug Act of 1906 aim to do?

A

Improve the quality and labeling of drugs and named the United States Pharmacopeia as the official source of drug information

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10
Q

The Harrison Narcotic Act of 1914 attempted to do what?

A

Limit the indiscriminate use of highly addicting drugs by regulating the transportation, manufacture, sale and use of opium, cocaine, and their compounds and derivatives

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11
Q

What amendment required that pharmacists have verbal or written prescription from a physician to dispense certain drugs?

A

Durham-Humphrey Amendment to the 1938 Act

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12
Q

The FDA was empowered by what act to enforce premarket safety standards for drugs

A

The Federal Food, Drug and Cosmetic Act of 1938

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13
Q

What act created the 5 schedules of controlled substances?

A

Controlled Substance Act of 1970

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14
Q

Define “Schedule I”

A

High abuse potential, may lead to dependance, no medical indications

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15
Q

Define “Schedule II”

A

High abuse potential, may lead to dependance, has accepted medical indications.

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16
Q

Define “Schedule III”

A

Less abuse potential than Schedule I or II, may lead to moderate to low dependance or high psychological dependance, has accepted medical indications

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17
Q

Define “Schedule IV”

A

Low abuse potential compared to Schedule III, may lead to limited psychological or physical dependance, has accepted medical indications

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18
Q

Define “Schedule V”

A

Lower abuse potential compared to Schedule IV, may lead to limited psychological or physical dependance, has accepted medical indications

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19
Q

Define “assay”

A

The purity of a given chemical in a preparation in the laboratory

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20
Q

Define “bioequivalance”

A

The relative therapeutic effectiveness of chemically equivalent drugs

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21
Q

What are the “6 Rights”

A

Right patient, Right medication, Right route, Right time, Right documentation, Right dose

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22
Q

Define “teratogenic drugs”

A

Drugs that may harm or kill a fetus

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23
Q

What tool is used to measure pediatric patients for medication administration?

A

Broselowe Tape

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24
Q

What are the two types of chemicals that bind to receptor sites?

A

Agonist and antagonist

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25
Define "efficacy"
Drugs ability to elicit it's effect
26
Define "affinity"
The force of attraction between the receptor site and drug
27
Define agonist and antagonist
Agonists have affinity and efficacy, antagonists have affinity but no efficacy
28
Define onset of action
Time from administration to reaching the minimum effective concentration.
29
What is the time when a drug is above the minimum effective concentration in the body?
Duration of Action
30
What is the Lethal Dose for 50 percent of the population and the Effective Dose for 50 percent of the population called?
Therapeutic Index (TI)
31
Define biologic half-life
Time for the body to clear half of the medication.
32
The nervous system breaks down into what two systems?
The central nervous system and the peripheral nervous system
33
What are the parts of the central nervous system?
The brain and spinal cord
34
What parts make up the peripheral nervous system?
Nervous tissue outside of the Central Nervous System
35
The peripheral nervous system breaks down into what two systems?
Autonomic and Somatic Nervous System's
36
What type of functions does the Somatic nervous system control?
Voluntary motor functions
37
What type of functions does the Autonomic Nervous System control?
Involuntary "automatic" functions
38
The Autonomic Nervous System breaks down into what two systems?
The Sympathetic and Parasympathetic Nervous Systems
39
Describe the Sympathetic Nervous System
Fight or Flight
40
Describe the Parasympathetic Nervous System
Feed or Breed
41
What is the difference between analgesia and anesthesia?
Analgesia is the absence of the sensation of pain, anesthesia is the absence of all sensation
42
What are "analgesics"?
Medications that relieve the sensation of pain
43
Define "adjunct medications"
Adjunct medications enhance the effect of other analgesics
44
Opium and all of it's derivatives reduce pain by being similar to what?
Similar to natural pain reducing peptides endorphins
45
How do endorphins and by extension opioids work to treat pain?
Work through opiate receptors and decrease pain by decreasing the sensory neurons ability to propagate pain impulse to the spinal cord and brain
46
What is the prototype drug for opioids?
Morphine
47
What are the three broad types of non-opioid analgesics?
Salicytes (Aspirin)Nonsteroidal anti-inflammatory Drugs or NSAIDS (Ibuprofen)Paraminophenal Derivatives (Acetaminophen)
48
What are opioid antagonists useful for?
Reversing the effects of opioid drugs, usually to treat respiratory depression.
49
Naloxone (Narcan) is the prototype drug of what class?
Opioid Antagonist
50
Neuroleptanesthesia combines what two effects?
Anesthesia and amnesia.
51
True or false, Anesthetics are usually only given one at a time.
False
52
How do anesthetics work?
Hyperpolarize neural membranes which makes depolarization more difficult. Thus decreasing firing rate of impulses and reducing propagation of action.
53
What do paramedics typically use anesthetics for?
Assist in intubation in rapid sequence intubation
54
Define "Sedation"
Sedation is a state of decreased anxiety and inhibitions
55
Define "Hypnosis"
Instigation of sleep
56
Sleep is categorized into what two categories?
REM and Non-REM sleep
57
What are the two pharmacological classes of anti-anxiety and sedative-hypnotic medications are?
Benzodiazepines and Barbiturates.
58
Differentiate between Benzodiazepines and Barbiturates
Benzodiazepines are usually prescribed orally and generally safe to treat general anxiety while Barbiturates have a broader depressant quality and higher abuse potential
59
What does GABA stand for in context of neurotransmitters?
Gamma-aminobutyric acid
60
GABA is the chief inhibitory neurotransmitter of what system?
Central Nervous System
61
What is the antagonist to Benzodiazepines?
Flumazenil (Romazaicone)
62
Define "Seizure"
Seizure is hyperactivity in either a section of the brain (partial seizure) or all of the brain (generalized seizure)
63
What channels in the neural membrane do antiseizure and antiepileptic medications target?
Sodium and Calcium ion channels
64
What are the two techniques that stimulate the Central Nervous System?
Increasing the effectiveness or release of excitatory neurotransmitters or Decreasing the effectiveness or release of inhibitory neurotransmitters
65
What are the 3 pharmacological classes of CNS stimulants?
Amphetamines, Methylphenidates, Mehtylxanthines
66
What do amphetamines like methamphetamine and dextroamphetamine do?
Increase the release of excitatory neurotransmitters including norepinephrine and dopamine.
67
What Psychotherapeutic medications treat what?
Mental dysfunction
68
What are Extra Pyramidal Symptoms (EPS)?
Common side effects of antipsychotic medications which include muscle tremors.
69
Define "Neuroleptic"
Affecting the nerves
70
What are the two pharmaceuticals classes of antipsychotics and neuroleptics?
Phenothiazines, Butyrophenones
71
What are two medications to administer to every unknown unconscious?
Narcan and D50%
72
What is the difference between "lytic" and "mimetic"
Mimetic means to stimulate and lytics means to reduce the action of
73
What does Beta 1 receptor stimulation stimulate?
Heart
74
What does Beta 2 receptor stimulation stimulate?
Lungs
75
What does Alpha 1 receptor stimulation stimulate?
Vein and Arteriole constriction, Ejaculation
76
What does dopaminergic stimulation stimulate?
Vasodilation
77
What is the dosage for Epinephrine IV push?
0.3 mg - 1.0 mg
78
What is the dosage for dopamine infusion?
2-20 mcg/kg/min
79
What is the dosage for atropine iv push?
0.5 - 2.0 mg
80
What is the dosage for narcan iv push?
0.4 - 2.0 mg
81
What is the dosage for D50 iv push?
12.5 - 25 grams
82
What is the dosage for glucagon iv push?
1 mg
83
Amiodarone dose?
150 - 300 mg
84
What is the dosage for Epinephrine infusion?
1 to 4 mcg per min