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Flashcards in Pharmacology Deck (70)
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1

Agonist of muscarinic receptor

Muscarine

2

Antagonist of muscarinic receptor

Atropine

3

Agonist of nicotinic receptor

Nicotine

4

Antagonist of nicotinic receptor

Curare

5

Is a muscarininc receptor a G protein coupled or NT gated receptor?

G-protein coupled

6

Is a nicotinic receptor a G protein coupled or NT gated receptor?

NT gated

7

Is an adrenergic receptor a G protein coupled or NT gated receptor?

G-protein coupled

8

What is ACh made from? What enzyme?

Choline and Acetyl CoA
Choline acetyltransferase (ChAT)

9

What is ACh broken down into? What enzyme?

Choline and Acetic Acid
Acetylcholinesterase (AChE)

10

Sympathetic NS is which spinal levels?

T1-L2

11

Parasympathetic NS is which spinal levels?

Brain stem, S2-S4

12

What are the subtypes of nicotinic receptors?

Neuronal, muscle

13

What are the subtypes of muscarinic receptors?

M1 (gastric parietal cells)
M2 (heart - negative chronotropic effects)
M3 (GIT, lacrimal)
M4 (adrenal medulla, CNS)
M5 (CNS)

14

What does vesamicol?
What NT does it affect?
Does it increase or decrease activity?

Prevent ACh packing into vesicles?
ACh
Decrease

15

What does botulinum toxin do?
What NT does it affect?
Does it increase or decrease activity?

Prevents attachment/exocytosis of vesicles from presynaptic neuron?
ACh
Decrease

16

What does hemicholinium do?
What NT does it affect?
Does it increase or decrease activity?

Prevents re-uptake of choline to pre-synaptic neuron
ACh
Decrease

17

Tubocurarine

Compete with ACh for nicotinic ACh receptor
ACh
Decrease

18

Atropine

Compete with ACh for muscarinic ACh receptor
ACh
Decrease

19

Anticholinesterases

Inhibit breakdown of ACh to choline and acetic acid
ACh
INCREASE

20

What are the effects of NE binding to alpha 1 receptors?

EXCITATORY

Vasoconstriction (except heart, skeletal muscle, liver)
Sphincters close
Arrestor pilli contract
Radial muscle of pupil dilates

21

What are the effects of NE binding to alpha 2 receptors?

INHIBITORY

Feedback inhibition = inhibit NE release
Increase glucagon --> increase glucose

22

What are the effects of NE binding to beta 1 receptors?

HEART
Increase HR, increase contractility --> increase CO

KIDNEY
Increase renin --> increase BP

23

What are the effects of NE binding to beta 2 receptors?

Smooth muscle relaxation
LUNGS - bronchodilation
HEART, SKELETAL MUSCLE, LIVER - dilation

Increase glycogenolysis and gluconeogenesis --> increase glucose

24

What are the effects of NE binding to beta 3 receptors?

Lipolysis at adipose tissue

25

In blood vessels:

Alpha 1 receptors are found ____________ and are stimulated by _____________.
Beta 2 receptors are found ____________ and are stimulated by _____________.

Alpha 1 receptors are found NEAR THE NERVE and are stimulated by NERVES

Beta 2 receptors are found THROUGHOUT THE VESSEL and are stimulated by ADRENALINE FROM THE ADRENAL MEDULLA

26

At low epinephrine levels.....

At high epinephrine levels....

At low epinephrine levels - B2 are occupied (have high affinity --> dilation)

At high epinephrine levels - A1 are occupied (more of them --> constriction)

27

What do MAO inhibitors do?
What NT does it affect?
Does it increase or decrease activity?

Antidepressants
Prevent action of monoamine oxidase (MAO) in pre-synaptic neuron (i.e., prevents NE breakdown)
NE
Increase

28

What do COMT inhibitors do?
What NT does it affect?
Does it increase or decrease activity?

Anti-parkinson's
Prevent action of COMT in post-synaptic neuron (i.e., prevents NE breakdown)
NE
Increase

29

What do NE re-uptake inhibitors do? EXAMPLE?
What NT does it affect?
Does it increase or decrease activity?

E.g., coccaine
Prevent re-uptake of NE to pre-synaptic neuron
NE
Increase

30

What does reserpine do?
What NT does it affect?
Does it increase or decrease activity?

Prevents packaging of NE into vesicles?
NE
Decrease