Pharmacology Flashcards
(23 cards)
What are alkylating agents used for?
Leukemia and lymphoma
What are traditional alkylating agents used for?
Lymphoid and myeloid tumors
What drug causes hemorrhagic cystitis?
Cyclophosphamide
What reduces Cyclophosphamide toxicity?
MESNA
What are good CNS penetrating drugs?
Carmustine
Iomustine
What are Carmustine/Iomustine used to treat?
Brain tumor
Leukemia
What are non classical alkylating agents used to treat?
Leukemia
Lymphoma
What are platinum analogs used for?
Solid tumors
What are antimetabolites used for?
All tumors
What causes Hand Foot syndrome?
5-FU
What is Cytarabine used for?
Soft tissue tumors
What class of drugs has major interactions when given with allopurinol?
Purine antagonists
What are purine antagonists used to treat?
Lymphoid and myeloid tumors
What are taxanes used for?
Solid tumors
What is the least bone marrow suppressing cancer drug?
Vincristine
Treatment limiting vinca and taxane side effects:
Peripheral and autonomic neuropathy
Bleomycin life time limiting dose side effect
Pulmonary toxicity
Inhibits phosphorylation and translocation to form philadelphia chromosome:
Imatinib
Philly chromosome is linked to what cancer?
CML
Used as anti-VEGFR for metasteses?
Bevacizumab
Used for anti epidermal growth factor receptor:
Cetuximab
Used in all HER-2 positive cancers:
Trastuzumab
Destroys all CD20 positive B cells:
Rituximab
