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Pharmacology Flashcards

(52 cards)

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1
Q

Drug reaction causing hyperprolactinemia

A

-Typical antipsychotics (Haloperidol)
-Atypical antipsychotics
(Quetiapine)
-Metoclopramide
-Methyldopa

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2
Q

Drug reaction causing SIADH

A

-Carbamezepine
-Cyclphosphamide
-SSRI’s
(Mnemonic: Can’t Concentrate Serum Sodium)

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3
Q

Drug reaction causing Acute cholestatic Hepatitis/jaundice

A

Macrolides (erythromycin)

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4
Q

Drug reaction causing Diarrhea

A
  • Lipid lowering agents (Ezetimibe, orlistat)
  • Cholinesterase inhibitors
  • antidiabetics (metformin, acarbose, pramlintide)
  • Quinidine
  • SSRI’s
  • Macrolides (erythromycin)
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5
Q

Drug reaction causing Hepatic necrosis

A

-Halothene
-Amanita Phalloides (death cap mushroom)
-Valporate
-Acetaminophen
(HAVAc)

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6
Q

Drug reaction causing Hepatitis

A
  • Rifampin
  • Isoniazid
  • Pyrazinamide
  • Statins
  • Fibrates
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7
Q

Drug reaction causing Pill induced esophagitis

A
  • NSAIDS
  • Bisphosphonates
  • Ferrous Sulfate
  • Potassium Chloride
  • Tetracyclines
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8
Q

Drug reaction causing Pancreatitis

A

-Didanosine
-Corticosteroids
-Alcohol
-Valproic acid
-Azathioprine
Diuretics (Furosemide, HCTZ)

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9
Q

Drug reaction causing Pseudomembranous colitis

A
  • Cephalosporins
  • Ampicillin
  • Clindamycin
  • Fluoroquinolines
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10
Q

Drug reaction causing Hyperglycemia

A

-Tacrolimus
-Protease inhibitors
-Niacin
-HCTZ
-Corticosteroids
(Mnemonic: The People Need Hard Candy)

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11
Q

Drug reaction causing Agranulocytosis (Severe decrease in WBCs esp neutrophils)

A
  • Clozapine
  • Carbamezapine
  • Propylthiouracil
  • Methimazole
  • Colchicine
  • Ganciclovir

(Mnemonic: Can Cause Pretty Major Collapse of Granulocytes)

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12
Q

Drug reaction causing Aplastic anemia

A
  • Carbamezapine
  • Methimazole
  • NSAIDs
  • Benzene
  • Chloramphenicol
  • Propylthiouracil

(Mnemonic: Can’t Make New Blood Cells Properly)

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13
Q

Drug reaction causing Eosinophilia and systemic symptoms (DRESS)

A
  • Allopurinol
  • Anticonvulsants
  • Antibiotics
  • Sulfa drugs

Tx: Stop offending drug, give corticosteroids)

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14
Q

Drug reaction causing Direct Coombs positive hemolytic anemia (autoimmune destruction of red blood cells)

A
  • MethylDopa
  • Cephalosporins
  • Penicillin

(Mnemonic: Direct Coombs Positive)

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15
Q

Drug reaction causing decreased platelets

A
  • Heparin
  • Vancomycin
  • Linezolid

(Mnemonic: Help, Very Low platelets)

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16
Q

Drug reaction causing Gingival hyperplasia

A
  • Cyclosporine
  • Ca+ channel blockers
  • Phenytoin

Mnemonic: Can Cause Puffy gums

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17
Q

Drug reaction causing Gout/hyperuricemia

A
  • Pyrazinamide
  • Thiazides
  • Furosemide
  • Niacin
  • Clyclosporin
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18
Q

Drug reaction causing myopathy

A

-Hydroxychoroquine
-Statins
-Niacin
-Fibrates
-Daptomycin
-Colchicine
-Penicillamine
-Interferon-A
-Glucocorticoids
(Mnemonic: stop fishy drugs causing pain in glutes

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19
Q

Drug reaction causing Photsensitivity

A
  • Sulfamides
  • mail adobe
  • 5-FU-Tetracycline
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20
Q

Drug reaction causing Parkinson’s-like syndrome

A
  • Antipsychotics
  • Reserpine
  • Metoclopramide
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21
Q

Drug reaction causing Pseudotumor cerebri

Study These Flashcards
A
  • Tetracyclines
  • Vitamin A
  • Growth hormones
22
Q

Drug reaction causing Peripheral neuropathy

Study These Flashcards
A
  • Vincristine

- Phenytoin

23
Q

Drug reaction causing Seizures

Study These Flashcards
A
  • Imipenam/Cilastatin
  • Isoniazid
  • Bupropion
  • Tramadol
  • Enflurane

(Mnemonic: with seizures I BITE my tongue)

24
Q

Drug reaction causing Tardive dyskinesia

Study These Flashcards
A
  • Antipsychotics

- Metoclopramide

25
Drug reaction causing Visual defects
- Topiramate (blurred vision, diplopia, haloes) - Digoxin (yellow vision) - Isoniazid (optic neuropathy/color vision change) - Vigabatrin (Bilateral visual field defects) - Ethambutol (color vision changes) - PDE-5 inhibitors like sildinafel aka viagra (blue vision) viagra blues
26
Drug reaction causing Hemorrhagic cystitis
- Cyclophosphamide | - Ifosfamide
27
Drug reaction causing Fanconi syndrome
- Cisplatin - Ifosfamide - expired tetracyclines (doxy, mino) - tenofivir
28
Drug reaction causing Interstitial nephritis
- PPIs - Penicillins - furosemide - sulfa drugs
29
Drug reaction causing Pulmonary fibrosis
- Methotrexate - Nitrofurantoin - Carmustine - Bleomycin - Busulfan - Amiodarone
30
Drug reaction causing Antimuscularinic symptoms
-sympathetic -cant see (dilation), cant pee (relaxes bladder) cant shit (relaxes bowel) -drugs: H1 blockers (loratidine) Atropine TCAs (tryptalines) Antipsychotics (haloperidol)
31
Disulfiram like reaction (hangover)
- first generation sulfonylureas; acetohexamide) - Metronidazole - Cephalosporins - Griseofulvin - Procarbazine mnemonic: Sorry Molly, Can’t Go Party
32
Drug reaction causing Nephrotoxicity/ototoxicity
- Vancomycin - amphotericin B - Loop diuretics - Aminoglycosides - cisPlatin Very Bad Listeners And Pissers.
33
Sulfa drugs
- Sulfonamide antibiotics - Sulfasalazine - Acetazolamide - Celecoxib - Probenecid - Thiazides - Furosemide - Sulfonylureas Some Sulfa Allergies Cause PROblems. Thats FUR sure
34
Cytochrome p-450 inducers
``` Modafinil Chronic alcohol St. John’s wort Phenytoin Phenobarbital Nevirapine Rifampin Griseofulvin Carbamezapine ``` Some chronic alcoholics Steal Phen Phen and never Refuse Greasy Carbs
35
Antimicrobial Drugs names - navir - Ovir - Ivir
``` -Protease inhibitor (Navir tease a PRO) -DNA polymerase inhibitor (Acyclovir) -Neuramindase inhibitor (oseltamivir) ```
36
CNS drug names: - azine - ipramine, triptyline - triptan - Zelma, zolam
- typical antipsychotic - TCAs - 5-HT agonist (sumatriptan) - benzodiazepine
37
Autonomic drug names: - chol - curium, curonium - olol - stigmine - terol - zosin
- cholinergic agonist (Bethanechol, cabachol) - Nondepolarizing paralytic; Atracurium, vecuronium - B-blocker - AChE inhibitor (neostigmine) - B2 agonist (albuterol) - A1 blocker (prazosin)
38
Drug names: - Dronate - gliptin - glutazone - Limus - prazole - prost - sentan - tidine - tropin
- bisphosphonate (alendronate) - DPP-4 inhibitors (sitagliptin) - PPAR gamma activator (rosiglitazone) - calcineurin inhibitor (eeverolimus, tacrolimus) - PPI (omeprazole) - Prostaglandin analog (Latanoprost) - endothelium receptor antagonist (Bosentan) - H2 blocker (Cimetidine) - pituitary hormone (somatotropin)
39
Monoclonal antibodies: - ximab - zumab - mumab
- chimeric human-mouse monoclonal antibody (Rituximab) - Humanized mouse monoclonal Ab (bevacizumab) - Human monoclonal Ab (Ipilmumab)
40
Drugs names that target Intracellular molecules: - tinib - zomib - ciclib
- Tyrosine kinase inhibitor (imatinib) - Proteosome inhibitor (Bortezomib) - Cyclin dependent kinase ibhibitors (Palbociclib)
41
Drug names for Receptor fusion proteins: | -cept
-TNF-a blocker (Etanercept)
42
Interleukin receptor modulators (antagonists and agonists) - leukin - kinra
- IL-2 agonist/analog (Aldesleukin) | - Interleukin receptor blocker (anakinra)
43
Typical antipsychotics | -azines
- Haloperidol - Pimozide - trifluoperazine - fluphenazine - thioridazine - chlorpromazine “Typical az (azine) HAL
44
High potency typical antipsychotics
-Trifluoperazine,Fluphenazine Haloperidol (Try to Fly High) -More neurological side effects; (extrapyramidal symptoms vs low potency antipsychotics)
45
Low potency typical antipsychotics
Chlorpromazine, thriodazine - More anticholinergic, antihistamine, a1 blockade effects. (Vs high potency typical antipsychotics) - Chlorpromazine-corneal deposits - Thioridazine -retinal deposits
46
Typical antipsychotics Side Effects:
EPS (extrapyrimidal symptoms): -Acute dystonia (Hours to days) -Akathisia (restelessness) -Parkinsonism (bradykinesia) (Days to months) -Tardive dyskinesia (months to years)
47
Tx of Tardive dyskinesia caused by typical antipsychotics
-Switch to atypical antipsychotics (clozapine, tetrabenazine, reserpine)
48
Atypical antipsychotics - apine - idone
- Schizophrenia negative and positive symptoms - Give clonazine if: - suicidal schizophrenia - treatment resistent schizo - schizoaffective disorder
49
Schizophrenia positive symptoms
- Delusions - Hallucinaitons - Disorganized speech - Disorganized or catatonic behavior
50
Schizophrenic negative symptoms
- Affective flattening (lack of emotional expression) - Avolition (lack of motivation) - Anhedonia (lack of pleasure) - Asociality - Alogia (lack of personal content in speech, providing bare minimum communication)
51
Atypical antipsychotics side effects:
-“Pines”-metabolic syndrome (weight gain, DM, hyperlipidemia) -Clozapine-agranulocytosis (CLozely monitor WBCs and seizures) Risperidone-hyperprlactinemia (amenorrhea, galactorrhea, gynecomastia)
52
SNRI’s (serotonin and NE reputable inhibitors)
-mnemonic: SNRI DVDs with Mi Love. Serious Nostalgia Renting Intimate DVD’s with Mi Love Desvenlafaxine Venlafaxine Duloxetine Milnacipran Levmilnacipran (Note: No other drugs in the antidepressant category start with D or V)

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