Pharmacology

Question 1

Pharmacology

Answer 1

Study of substances that interact with the living system through chemicals

Question 2

Pharmakinetics

Answer 2

Action of the body on the drugs

Question 3

Governed by pharmacokinetics(4)

Answer 3

Absorption
Distribution
Metabolism
Elimination of drugs

Question 4

Absorption: 2 primary routes

Answer 4

1. Enteral

2. Parenteral

Question 5

Enteral administration

Answer 5

Through the alimentary canal

Question 6

3 types of enteral administration

Answer 6

1. Oral
2. Sublingual
3. Rectal

Question 7

Parenteral administration

Answer 7

Not through alimentary canal

Question 8

2 types of parenteral administration

Answer 8

Inhilation and injection

Question 9

Intravenous

Answer 9

Fast absorption

Question 10

Intramuscular

Answer 10

Deltoid
Vastus lateralis
Gmax

Question 11

Intra arterial

Answer 11

Dx procedure

Question 12

Subcutaneous

Answer 12

Local response

Question 13

Distribution

Answer 13

Drug will bind to a protein (ie albumin)

Then it will attach to the receptor and is synthesized in the liver

Question 14

Warfarin (coumadin)

Answer 14

99% protein bound

Question 15

Albumin

Answer 15

Synthesized in the liver

Question 16

Bioavailability

Answer 16

Percent of drug molecules that reaches the bloodstream

i.e. 100g Aspirin = 50 g = 50%

Question 17

Metabolism

Answer 17

Process of breaking down drig molecules

Question 18

First pass metabolism

Answer 18

Liver (before it mix in the circulation it should pass first in the liver)

• has enzyme that decreases the effect of the drug
• from inactive to active form

Question 19

Main site of elimination

Answer 19

KIDNEYS

Question 20

Half-life

Answer 20

Amount of time for the remaining 50% of drug molecule to be eliminated

Question 21

Half-life of antibiotics

Answer 21

3 hours

Question 22

Half life of biogesic

Answer 22

2 hours

Question 23

Pharmacodynamics

Answer 23

Action of drugs in the body

Question 24

2 drug receptors (pharmacodynamics)

Answer 24

AGONIST DRUG

ANTAGONIST DRUG

Question 25

Agonist drug

Answer 25

Bind to a specific receptor that activate/stimulate

Question 26

Antagonist drug

Answer 26

Will bind then block/deactivate