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Endocrinology > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What drugs can be used to inhibit CRH secretion at the level of the hypothalamus? What effect will this have?

A

Bromocriptine and Peroglide (DA Agonists). - Decrease in ACTH and cortisol levels.

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2
Q

What drugs can be used to stimulate CRH secretion at the level of the hypothalamus? What effect will this have?

A

Cyproheptadine. - Increase ACTH and cortisol levels.

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3
Q

What drug can be used to inhibit ACTH secretion at the pituitary level? How does it work?

A

Dexamethasone (glucocorticoid analogue) - inhibits ACTH by negative feedback.

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4
Q

What drugs can be used to stimulate adrenal synthesis of cortisol?

A

ACTH analogues e.g. Synacthen.

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5
Q

What drugs can be used to inhibit adrenal synthesis of cortisol?

A

Aminoglutethimide, Metyrapone.

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6
Q

What drug can be used to destroy the adrenal cortex? Where does it affect?

A

Mitotane causes destruction of the ZF and ZF.

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7
Q

What drug can be used to mimic Cortisol?

A

Dexamethasone.

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8
Q

What drug can be used to mimic Aldosterone?

A

Fluorocortisol.

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9
Q

What are the side effects of drugs mimicking Cortisol?

A

Adrenal gland atrophy, Hypoadrenocorticism if stopped suddenly, Iatrogenic Cushing’s, PU, PD due to inhibition of ADH action.

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10
Q

What drug can be used to increase TSH release from the pituitary?

A

Protirelin (synthetic TRH) - used to test thyroid dysfunction (TRH stimulation test)

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11
Q

What drugs can be used to decrease TSH release from the pituitary?

A

Thyroxine or Triiodothyronine. - Used to test thyroid gland function (T3 suppression test)

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12
Q

What drug could be used to increase Thyroid hormone production in thyroid gland? Why is it not used?

A

TSH could be used, but it is not liscensed. It can be used to diagnose thyroid disorders.

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13
Q

What drugs can be used to decrease Thyroid hormone synthesis from the thyroid gland?

A

Radioisotopes of Iodide. - used to treat Hyperthyroidism. Also anti-thyroid drugs.

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14
Q

Give some examples of anti-thyroid drugs. What do they do?

A

Perchlorate & Thiocyanate compete with I for uptake by pump. Thioureylenes block TPO. Inorganic iodide can be used to manage hyperthyroidism.

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15
Q

What drug can be used to mimic T3 in Hypothyroid therapy?

A

Sodium Liothyronine (T3 ‘Tetroxine’)

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16
Q

What drug can be used to mimic T3 in Hypothyroid therapy?

A

Sodium Levothyroxine (T4 ‘Soloxine’)

17
Q

Are there any drugs that can be used to inhibit the actions of thyroid hormones?

A

No antagonists available, but Propanolol can be used to antagonise some of the CVS symptoms (Beta-blocker).

Endocrinology (7 decks)

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