Pharmacology Flashcards
(22 cards)
Dopamine D2 antagonism or partial agonism leads to …
Decreased positive sx
Serotonin 5HT1a partial agonist leads to
Decreased Anxio depressive sx
Cognitive improvement
5ht2a antagonism
Decreased negative sx
Improvement of EPS
5HT2c antagonism
Decreased anxiety sx, decreased negative sx, better cognition
BUT hypotension, sedation and increased weight
Alpha 1 antagonism
Orthostatic hypotension Dizziness Reflex tachycardia Sedation Hypersalivation Incontienece PRIAPISM
Alpha 2 antagonism
Sexual dysfunction
Alpha 2 agonism
Improved cognitive function
Histamine H1 antagonism
Anti emetic
BUT Sedation, weight gain and orthostatic hypotension
M1 antagonism
Decreased EPS Dry mouth Blurry vision Constipation Sinus Tachycardia * Changes in QRS Memory problems Sedation
Medication contraindicated with clozapine
Carbamazepine
Medication other than clozapine that can give agranulocytosis
Carbamazepine
Green light clozapine
WBC >3.5
ANC >2.0
Yellow light clozapine
WBC 3-3.5
ANC 1.5-2
CBC 2x per week until green
Keep taking clozapine, take vital signs
Red light clozapine
WBC <3
ANC <1.5
Redo CBC in 24 hrs if continues STOP
CBC once a week for a month
Contact hematology
Carbamazepine side effects
Decreased T3 and T4 SIADH agranulocytosis Can give sjs, ten Ataxia, sedation, GI
Lurasidone
Metabolized 3A4
Start 40 mg ad 160
Need to take with 350 cal
Weight neutral, no etc problem
Ziprasidone
80-160mg But more efficacious >120 mg Has antihistaminic properties, blocks H1 Take with 500cal No weight gain
GABA A
Rapid
GABA B
Slow
Glutamate
Fast action
Precursor of GABA
Renal failure extends the half life of
Venlafaxine
Paroxetine
Mirtazapine
Buproprion
Mirtazapine mechanism of action
Alpha 1 antagonist
5HT2 and 3 antagonist
H1 and muscarinic antagonist
