Pharmacology Capstone Flashcards Preview

Neuroscience I Test 3 > Pharmacology Capstone > Flashcards

Flashcards in Pharmacology Capstone Deck (21):
1

Sympathetic Innervation to Cardiac and Smooth M

Preganglionic: ACh to nicotinic R
Postganglionic: NE to alpha and beta R

2

Sympathetic Innervation to Renal Vascular SM

Preganglionic: ACh to nicotinic R
Postganglionic: dopamine to dopamine R

3

Parasympathetic Innervation of Cardiac and Smooth Muscle

Long Preganglionic: ACh to Nicotinic R
Short postganglionic: ACh to Muscarinic R

4

M2 and M3 receptors

Smooth muscle mAChRs--M2 R is predominant cardiac M mAChR

5

End result of alpha 1 receptor activation

Muscle contraction

6

Activation of alpha 2 receptor

Vascular SM contraction, decreased insulin secretion, dec release of NE

7

Activation of beta 1 receptors

Inc force and rate of heart contraction
AV nodal conduction velocity

8

Activation B2 receptor

Vascular, bronchial, genitourinary, and GI SM to relax

9

Activation of of B3 receptor

Lipolysis

10

Alpha 1 receptor

-act thru Gq: inc PLC, IP3/DAG
-Epi>NE
-acts on vascular SM, GU SM, liver, intestinal SM
-responses: contraction, inc contractile force

11

Alpha 2 receptor

-Gi: dec adenylyl cyclase
-Epi>NE
-found presynaptically in CNS, dec insulin secretion, dec release of NE

12

Beta 1 receptor

-Gs: inc adenylyl cyclase
-Epi=NE
-heart: inc force of contraction

13

Beta 2 receptor

-Gs: inc adenylyl cyclase
-Epi>NE
-SM: relaxation

14

Beta 3 receptor

-Gs: inc adenylyl cyclase
-NE>Epi
-adipose tissue: Lipolysis

15

Innervation of Sweat Glands

Preganglionic: release of ACh to nicotinic R
Postganglionic: release of ACh to muscarinic R on sweat glands

16

Endothelium Derived Relaxing Factor

SM of blood vessels is not innervated by PS neurons but is innervated by sympathetic neurons
-blood vessel endothelial cells release a short lived vasodilator called EDRF, now known as NO
-in response to AP, PS neurons release ACh
-the circulating ACh activates mAChRs
-NO is produced by endothelial cells and diffuses back to SM cells surrounding blood vessels which it causes relaxation

17

Rule about alpha 1 adrenergic Rs

-stimulate contraction of all SM
-vascular SM--vasoconstriction
-glandular SM--secretion

18

Beta 2 adrenergic receptor Rule

-relax SM
-vascular SM--vasodilation

19

Muscarinic Rs rule

-contract SM
-NO acts on them to relax and vasodilate vessels

20

Parasympathetic Tone

Rest and digest
-cholinergic effects

Salivation
Lacrimation
Pupil constriction
Dec in HR
Urination
Inc secretions
Inc GI track motility

21

Sympathetic tone

Fight or flight
Adrenergic

Pupil dilation
Inc in HR
Urinary retention
Dec secretions
dec GI track motility