Pharmacology: Drug Reactions

Question 1

Coronary vasospasm

Answer 1

Cocaine

Sumatriptan

Question 2

Cutaneous flushing

Answer 2

VANC
Vancomycin
Adenosine
Niacin
CCB

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicin (Adriamycin): intercalates DNA

Daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III (sotalol)
Class IA (quinidine)

Question 5

Agranulocytosis

Answer 5

Agranulocytosis Could Certainly Cause Pretty Major Damage
Clozapine
CBZ
Colchicine
PTU
Methimazole
Dapsone

Question 6

Aplastic anemia (BM failure)

Answer 6

Chloramphenicol
Benzene
NSAIDs
PTU
Methimazole
Microtubule inhibitors: Vinblastine, paclitaxol
Antimetabolites: 5-FU, 6-MP, MTX
Antitumor abx: Etoposide
Other chemo: hydroxyurea

Question 7

Hemolysis in G6PD pts

Answer 7

Hemolysis IS PAIN in g6pD or Hemolysis IS a PAIN in the Dierriere!
Isoniazid
Sulfonamides
Primaquine/Chloroquine
Aspirin
Ibuprofen
Nitrofurantoin
Dapsone

Question 8

Direct Coombs positive hemolytic anemia

Answer 8

Methyldopa

Question 9

Megaloblastic anemia

Answer 9

having a blast with PMS
Phenytoin
MTX
Sulfa drugs

Question 10

Gray baby syndrome

Answer 10

Chloramphenicol

Question 11

Thrombotic complications

Answer 11

OCPs

Question 12

Cough

Answer 12

ACE inhibitors (NOT ARBs)

Question 13

Pulmonary fibrosis

Answer 13

tough to BLAB when you have pulmonary fibrosis
BLeomycin
Amiodarone
Busulfan

Question 14

Acute cholestatic hepatitis

Answer 14

Erythromycin

Question 15

Focal to massive hepatic necrosis

Answer 15

liver HAVAc
Halothane (inhaled anesthetic, also risk for malignant hyperthermia)
Acetominophen
VPA
Amantia phallodies (death cap mushroom, inhibits RNA pol II)

Question 16

Hepatitis

Answer 16

INH

Question 17

Pseudomembranous colitis

Answer 17

Clindamycin

Ampicillin (AMPed up PCN, HELPSS kill Enterococci)

Question 18

Adrenocortical insufficiency

Answer 18

Glucocorticoid withdrawal (HPA suppression)

Question 19

Gynecomastia

Answer 19

Some Drugs Create AwesomE Knockers
Spirnolactone
Digoxin
Cimetidine
Alcohol
Estrogen
Ketoconazole

Question 20

Hot flashes

Answer 20

Tamoxifen: anti-estrogen in breast, pro-estrogen in uterus (partial on endometrium) and bone
Clomiphene

Question 21

Hypothyroidism

Answer 21

Lithium
Amiodarone
Sulfonamides

Question 22

Hyperglycemia

Answer 22

Niacin
Tacrolimus (immunosuppressant, also causes PRES!)
Protease inhibitors

Question 23

Fat redistribution

Answer 23

Glucocorticoids
Protease inhibitors (NAVIR tease a protease!)

Question 24

Gingival hyperplasia

Answer 24

Phenytoin

Verapamil

Question 25

Gout

Answer 25

``` Furosemide Thiazides Niacin Cyclosporine Pyrazinamide (anti-TB, inhibits mycolic acid production by inhibiting fatty acid synthase I) ```

Question 26

Myopathies

Answer 26

Fish N CHIPS Give you myopathies Fibrates Niacin Colchicine Hydroxychloroquine (aka Plaquenil): for RA, lupus Interferon-alpha: block viral replication, used for Hep B/C, and Kaposi's Penicillinamine: heavy metal chelator (Pb, As, Au, Cu -- vs. Fe is deferoxamine) Statins Glucocorticoids

Question 27

Osteoporosis

Answer 27

Corticosteroids | Heparin

Question 28

Photosensitivity

Answer 28

SAT for a photo Sulfonamides/sulfa drugs Amiodarone Tetracycline

Question 29

Rash (SJS)

Answer 29

``` bad rash after a PEC SLAPP Penicillin Ethosuximide CBZ Sulfa drugs Lamotrigine Phenytoin Phenobarbital ```

Question 30

SLE-like syndrome

Answer 30

``` it's not HIPP to have lupus Hydralazine INH Procainamide Phenytoin Also: quinidine, minocycline, dapsone ```

Question 31

Tendonitis, tendon rupture, and cartilage damage (kids)

Answer 31

Fluoroquinolones

Question 32

Diabetes insipidus

Answer 32

Lithium (nephrogenic) | Demeclocycline (a tetrocycline abx - used to treat SIADH!)

Question 33

Fanconi's syndrome

Answer 33

Expired tetracycline

Question 34

Interstitial nephritis

Answer 34

Methicillin NSAIDs Furosemide Rifampin

Question 35

Hemorrhagic cystitis

Answer 35

Cyclophosphamide Ifofosamide (Give mesna)

Question 36

SIADH

Answer 36

CBZ: increases and potentiates ADH Cyclophosphamide: direct effect on renal tubules, incr H2O retention

Question 37

Cinconchism (flushed, sweaty skin, tinnitus, blurred vision, lichenoid photosensitivity)

Answer 37

(AKA quinism, a pathological condition in humans caused by an overdose of quinine or its natural source, cinchona bark) Quinidine Quinine

Question 38

Parkinson-like syndrome

Answer 38

Anti-psychotics (DA antag) Reserpine (inhibits VMAT) Metoclopramide (dopamine D2 R antagonist in in the chemoreceptor trigger zone [CTZ], prevents N/V)

Question 39

Seizures

Answer 39

Bupropion (in bulimic patients) Imipenem/cilastin (CNS toxicity at high levels) Isoniazid

Question 40

Tardive dyskinesia

Answer 40

Antipsychotics

Question 41

Antimuscarinic (Hot/Red/Dry/Mad)

Answer 41

Atropine TCAs H1 blockers Neuroleptics

Question 42

Disulfiram-like reaction

Answer 42

Metronidazole certain Cephalosporins Procarbazine (when combined with EtOH) 1st generation Sulfonylureas (tolbutamide, chlorpropamide)

Question 43

Nephrotoxicity/ototoxcity

Answer 43

Aminoglycosides Vancomycin Loop diuretics Cisplatin

Question 44

Cholinergic

Answer 44

Digoxin | Organophosphates

Question 45

Lactic acidosis

Answer 45

Metformin

Question 46

Check LFTs

Answer 46

Statins | TZDs (Pioglitazone, rosiglitazone)

Question 46

Sulfa drugs

Answer 46

``` Popular FACTSSS Probenecid (incr uric acid excretion) Furosemide Acetazolamide Celecoxib Thiazides Sulfonamide antibiotics Sulfasalazine Sulfonylureas ```