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pharmacology lectures Flashcards

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1
Q

what do you prescribe for streptococcal pharyngitis?

A

penicillin V 500mg qds for 10 days

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2
Q

how do antibiotics work?

A

antibiotics are molecules that work by binding a target site on bacteria

these target sites are defined as points of biochemical reaction crucial to the survival of the bacterium

the crucial binding site will vary with antibiotic class.

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3
Q

how do penicillins work?

A

they act on the cell wall of the bacteria and inhibits cell wall synthesis.

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4
Q

what are beta lactams?

A

penicillins
cephalosorins (cefalexin, cefuroxime, cefotaxime, cerftriaxone)
carbapenems (meropenem, ertapenem)
monobactams (aztreonam)

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5
Q

what types of antibiotics prevent nucleic acid synthesis?

A

quinolones

rifampin

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6
Q

what antibiotics prevent protein synthesis?

A

aminoglycosides (gentamicin)
tetracyclines (doxycycline)
Lincosamides (clindamycin)
macrolides (erythromycin, clarithromycin, azithromycin)

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7
Q

what antibiotics inhibit the metabolic pathways?

A

they do this by inhibiting folate synthesis

sulphonamides - sulphamethoxazole

trimethoprim - co-trimoxazole

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8
Q

what are some gram positive resistant organisms

A

MRSA - methicillin resistant stahylococcus aureus

VRE - vancomycin resistant enterococci (caused by cephalosporin use)

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9
Q

what causes resistance to certain penicillins?

what has been done to get around this resistance?

A

the production of beta lactase enzymes which hydrolyse penicillins

we add something that inhibits the beta lactamase eg clavulanate or tazobactam

amoxicillin plus clavulanate = co-amoxiclav

pipericillin plus tazobactam = tazocin

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10
Q

what antibiotics can be used when there is resistance to all other antibiotics?

A

carbapenems

however there is now also resistance to this

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11
Q

if someone has suspected sepsis what should you prescribe within the hour?

A

antibiotics

piperacillin/tazobactam and clindamycin

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12
Q

what should you treat group a beta haemolytic streptococcus skin infection with?

A

benzyl penicillin and clindamycin

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13
Q

what things do you need to consider when deciding if antibiotics are safe for the patient?

A 
intolerance
allergy and anaphylaxis 
side effects 
age 
renal and liver function 
pregnancy and breast feeding 
drug interaction 
risk of C.diff
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14
Q

what are cephalosporins good for?

A

good for people with penicillin allergy
work against some of the penicillin-resistant bacteria
they can get into different parts of the body e.g. meningitis

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15
Q

why are beta-lactams good for gram-positive bacteria?

A

because gram-positive bacteria have a thick cell wall and beta-lactams inhibit cell wall synthesis

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16
Q

what is the first line agent for cellulitis ?

A

flucloxacillin

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17
Q

what is the first line for strep throat?

A

PO penicillin V

IV benzylpenicillin

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18
Q

what is first line for pneumonia?

A

PO amoxicillin

IV benzylpencillin

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19
Q

what are forms of glycopeptides?

when are they used?

A

vancomycin
teicoplanin

only used for gram positive bacteria
use in MRSA
can be used in penicillin allergy

have to be used with caution because can cause renal impairment

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20
Q

when would you use a macrolide?

A

clarithromycin and erythromycin

s. aureus
beta haemolytic strep
atypical pneumonia pathogens (e.g. legionella, mycoplasma)

can be used in penicillin allergy
and in severe pneumonia

they work just as well orally and intravenously

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21
Q

when is it good to use clindamycin?

A

gram positive

can be used in cellulitis if penicillin allergic

can be used for necrotising fasciitis (turns off nasty towns made by gram positive bugs)

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22
Q

when is it good to use tetracyclines ?

A

e.g. doxycycline

broad spectrum but mainly for gram positive
can use in cellulitis is penicillin allergy
can be used in chest infections

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23
Q

what type of infections are caused by gram negative bacteria?

A

UTIs
diarrhoea
intra-abdominal infections
gall bladder infections - billiard sepsis

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24
Q

what is the main draw back of ciprofloxacin?

A

it can cause C.diff

so tend to avoid in elderly patients

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25
why is ciprofloxacin good and when is it used ?
it gets everywhere in the body - head, bowel, skin not many bugs are resistant to it used for gram negative used in UTI, gall bladder infections, abdominal infections
26
what is trimethoprim used for?
it is broad spectrum but is mainly used for gram negatives used in UTIs
27
when is nitrofurantoin used?
gram negative - UTIs
28
why are penicillins not good for gram negatives?
because gram negatives produce lots of the enzymes that hydrolyse penicillin however some beta lactams can be used for gram negatives e.g. cephalosporins
29
respiratory drug nomenclature
.....mab = monoclonal antibody (reslizumab) .....sone = corticosteroid (dexamethasone) .....terol - bronchodilators (salmeterol) .....lone = corticosteroid (prednisolone) ....nib = kinase inhibitor (nintedanib)
30
what are inhaled pharmacological and what are mechanisms of administration ? what are the delivery systems for inhaled drugs?
inhaled medicines are delivered directly to the lung via the oral or nasal route inhaler devices allow drugs to penetrate deep into the lung and to achieve the correct dose, inhalers deliver dry powder formulation nebulisers deliver medication in theorem of aerosols pressurised metered-dose inhalers spacer devices dry powder inhalers nebulisers
31
what are some causes of bronchocontriction?
asthma copd constriction of the airways due to tightening of airway smooth muscle, luminal occlusion by mucus and plasma and airway wall thickening. Leads to airflow obstruction
32
what two main categories are bronchodilators divided into?
adrenergic (sympathetic) - bronchodilator anti-cholinergic (parasympathetic - block bronchoconstriction)
33
how do bronchodilators work?
they are beta2 adrenoreceptor agonists they act on beta2 adrenoreceptors to cause smooth muscle relaxation and bronchodilation, they also inhibit histamine resale from lung mast cells.
34
what are some examples of bronchodilators ?
SABA | LABA
35
what is the muscarinic receptor activation for bronchoconstriction?
acetylcholine causes muscle contraction by acting on the muscaranic receptors on the smooth muscle cells which causes muscle contraction in the airways. Act is released by parasympathetic nerves
36
how do anti-cholinergic prevent bronhoconstriction?
acetylycholine antagonists (anticholinergics) block acetylcholine binding to muscarinic receptors and prevents bronchoconstriction. anticholinergic compounds block muscarinic receptors on airway smooth muscle, glands and nerve to prevent muscle contraction, gland secretions and enhance neurotransmitter release.
37
what are some examples of muscarinic receptor antagonists?
ipratropium bromide tiotropium bromide atropine - old one that was used but has many side effects.
38
what drugs can be used for anti-inflammatory in lung disease?
glucocorticoids aka corticosteroids suppress inflammation via several mechanisms. they are the most effective anti-inflammatory for asthma (they improve QOL in patients with asthma, improve lung function, reduce frequency of exacerbations and can help to prevent irreversible airway changes how ever they are relatively ineffective in COPD, CF and IPF
39
what are the side effects of ICS?
high doses of ICS are often used in COPD they overuse can lead to long term side effects such as: loss of bone density adrenal suppression cataracts, glaucoma titrate to the lowest effective dose to reduce the chances of side effects
40
how is bronchiectasis managed?
it is challenging antibiotics treat the infective elements of bronchiectasis physical therapies clear the air ways surgery and transplantation may be needed for severe disease strategies to reduce the symptoms - mucolytics - beta 2 agonists most useful in COPD/asthma/bronchiectasis overlap syndromes - anticholinergics have limited effect - ICS have limited effects
41
how is pulmonary fibrosis managed?
treatment is limited some forms of fibrosis respond to corticosteroids pirfenidone and nintedanib are new drugs that significantly slow the rate of disease progression in IPF
42
usually how long should a patient not eat before surgery?
6 hours
43
what is done if a patient has eaten in the past 6 hours but needs emergency surgery? or if they have a blockage meaning they have a full abdomen?
they have a rapid sequence induction quick hit short period of time which doesn't give time for aspiration reflux and aspiration of gastric contents
44
if someone is unstable, but needs emergency surgery what she be done before inducing anaesthesia?
pre-optimisation - invasive blood pressure monitoring - urinary catheter - central venous access - inotropic support - cardiac output monitoring - the broad aim of pre-optimisation is to mammies oxygen delivery peri-operatively to supra-normal levels.
45
what drugs should be omitted per-operatively in the elective surgeries?
> ACE inhibitors ("...prils") - stop 24 to 72 hours before > angiotensinogen receptor antagonists ('sartans") - stop 24-72 hours before > anti-tumour necrosis factor - stop 2 weeks before > platelet inhibitors - aspirin, clopidogrel, prasugrel - stop 7-10 days before > DOACS - stop 4 days before > rivaroxaban, apixaban, eidxoban - stop 3 days before
46
why are NSAIDS avoided with surgery?
they increase the risk of intraoperative bleeding do not use within 24-48 hours of operation because the increase the risk of post operative bleeding do not use in asthmatic can cause renal failure if given during blood loss or during episodes of hypotension avoid NSAIDS in those with renal impairment, hyperkalaemia, hypovolaemia, circulatory failure, severe liver dysfunction, cardiac disease, MI, CVA THEY SHOULD BE USED QITH GREAT CAUTION PERIOPERATIVELY
47
what things are often given intraoperatively ?
``` oxygen fluids blood/blood products antibiotics anaesthesia analgesia muscle relaxation ```
48
what are the common inhalation anaesthetic agent to keep the patient asleep?
desflurane - possible reduction in post operative cognitive dysfunction, rapid recovery particularly in the obese. however big contributor to global warming sevoflurane
49
what are the intravenous agents used to induce anaesthesia?
propofol - this is the one that should be used - can also be used for the maintenance of anaesthesia (know as total intravenous anaesthesia) ketamine - not often used
50
what are the two types of muscle relaxation?
depolarising - suxmethonium - short rapid onset and short duration and rapid offset- used in rapid sequence induction non-depolarising - rocuronium - takes longer to wash in and build up concentrations because it is a competitive block. Takes 3 or 4 minutes to work. wears off gradually, slow offset. Duration of onset can last from 20-40 minutes they lead to muscle relaxation and paralysis they all work by mimicking acetylcholine
51
what can be used to reverse neuromuscular block caused by rocuronium?
sugammadex
52
what things can be given postoperatively?
analgesia fluids/blood products inotropes/vasopressors antiemetics/anti-coagulants/antibiotics
53
what is the total blood volume for adults>
70 mls/kg
54
what are the different types of fluid?
crystalloids colloids - rarely used
55
what happens if you resuscitate someone with normal saline for a long period?
they become hypernatraemic they will also get hyperchloraemia they end up acidotic hyperchloraemia acidosis
56
how is glucose transported into cells?
it is co transported into cells with potassium so if you give someone loads of sugar it will drop their potassium
57
what are the different types of fluid loss?
sensible - fluid loss you can measure and see insensible - hard to measure
58
what do you need to consider when prescribing paracetamol?
``` liver impairment severe cachexia (less than 50kg) ```
59
what do you need to consider when prescribing NSAIDS?
renal impairment - so check renal function and platelet count risk of GI bleeding history of and ulcer if they have asthma concurrent medications: things that also increases risk of things mentioned above - warfarin, digoxin and steroids
60
what are common weak opioids?
Codeine Tramadol dihyrocodeine
61
after trying a weak opioid and it having minimal effect what might you try?
strong opioid - morphine - fentanyl - diamorphine - given primarily via injection or infusion - oxycodone - buprenorphine
62
what do you need to consider before starting a strong opioid?
ask the patient have they even taken before, how did they find it if they have? age and frailty - small doses may be needed any co-morbitities any reduced renal function (morphine in people with low renal function can cause more side effects so in people with eGFR<30 always use oxycodone) will they take them as prescribed? are they driving? patient concerns?
63
how potent is codeine and tramadol compared to oral morphine?
codeine and tramadol are 1/10th as potent as oral morphine.
64
what type of morphine and oxycodone would you prescribe for background pain?
modified release - 12 hours morphine (MST - tablet, Zomorph - capsule ) Oxycodone - oxycontin
65
what type of morphine and oxycodone would you prescribe for breakthrough pain?
immediate release duration of action = 4 hours morphine - oramorph (liquid), sevredol (tablet) oxycodone - oxynorm - liquid or capsule
66
what should you do when prescribing opioids?
always slow low titrate dose according to pain and PRN usage you should always prescribe PRN antiemetics and a stimulant laxative in case of the side effects
67
what should the PRN dose of opioids be?
PRN doses as a general rule are 1/6th of the 24hour dose
68
what are the side effects of morphine?
common - constipation, nausea, sedation, dry mouth Less frequent - psychomimetic effects, confusion, myoclonus rare - allergy, respiratory depression, pruritus
69
what opioids come in the form of patches?
Fentanyl and buprenorphine
70
when might opioid patches be needed? what are the problems with the patches?
if there are intolerable side effects if there are oral route difficulties - compliance or dysphagia renal impairment problems: takes 1-3 days to reach analgesic concentrations when first increased so no not use in acute pain needs to be applied to hairless, dry, non inflamed skin avoid heat pads as they will increases the rate of absorption
71
what are more renal friendly opioids?
fentanyl buprenorphine methadone alfentanil
72
what are the different types of pain?
nociceptive pain - pain that arises from actual or threatened damage to non-neural tissue and is due to activation of nociceptors Neuropathic pain - pain caused by a lesion or disease of the somatosensory nervous system nodplastic pain - pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence from disease or lesion of the somatosensory system causing pain.
73
what is allodynia?
when there is pain due to a stimulus that does not normally provoke pain
74
what is dysesthesia?
an unpleasant abnormal sensation, whether spontaneous or evoked
75
what is acute pain and chronic pain?
acute - less than 12 weeks | chronic - continuous pain lasting more than 12 weeks - can be cancer and non cancer chronic pain

Phase 3b (34 decks)

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