Pharmacology MCQ Flashcards
Glutamate acts at many receptors. Which one of the following statements regarding its ability to do this is FALSE?
a.It is a very flexible molecule
b.It can adopt different conformations
c.12 different rotational conformations (rotamers) are possible
d.It can rotate about two axes formed by alpha-beta and beta-gamma bonds
e.It can exist in an extended conformation
c?
Which one of the following statements best describes the mechanism of action of diazepam?
a. non-specific ion channel blocker
b. enhances the effects of endogenous GABA
c. stimulates noradrenaline release
d. directly activates GABAA receptors
e. blocks 5-HT reuptake
b?
The following are descriptions of the therapeutic effects of benzodiazepines – which one is FALSE?
Question 3Select one:
a.
Antipsychotic
b.
Hypnotic
c.
Muscle relaxant
d.
Anticonvulsant
e.
Anxiolytic
a
Which one of the following statements is FALSE?
Clinical depression:
Question 4Select one:
a.
is a self-limiting disease
b.
may be characterised by loss of appetite and weight loss
c.
is more prevalent in women
d.
is characterised by phobic delusions
e.
is characterised by low self-esteem
d
Concerning therapy of Parkinson’s disease, which one of the following would NOT be a useful treatment?
a.
Selegiline
b.
Bromocriptine
c.
L-DOPA
d.
Chlorpromazine
e.
Amantadine
d?
Which of the following statements is true?
Select one:
a.
Substance P and GABA are co-transmitted at nociceptor nerve terminals
b.
Ibuprofen increases prostaglandin synthesis
c.
The analgesic properties of morphine are caused largely by δ-opioid activation
d.
Activation of opioid receptors causes opening of K+-channels
e.
Descending 5-HT input to the spinal cord enhances pain sensations
b?
Which one of the following facts about epilepsy is FALSE?
Question 7Select one:
a.
There are around 500 sudden unexpected deaths form epilepsy each year in the UK.
b.
It affects around 1% of the population
c.
Up to 30% of drug refractory patients are not improved by surgical removal of the seizure focus
d.
Approximately 80,000 new cases are diagnosed each year
e.
30% of patients are refractory to current treatments
WHich is true
Select one:
a.
Opioid receptors are coupled to the Gq-signalling system
b.
Activation of cannabinoid receptors enhances noxious sensations
c.
Activation of opioid receptors causes opening of K+-channels
d.
Activation of cannabinoid receptors causes activation of adenylyl cyclase
e.
GABA and Substance P are co-transmitted at nociceptor nerve terminals
c
Which one of these statements about NMDA receptors is FALSE?
Question 9Select one:
a.
They are permeable to sodium
b.
They are regulated by magnesium ions
c.
They are activated by hyperpolarization
d.
They are permeable to calcium
e.
They are blocked by ketamine
c
egarding the metabolism of benzodiazepines (BZs), which of the following is FALSE?
Question 10Select one:
a.
2-keto BZs give rise to numerous active primary metabolites
b.
Triazolo BZs have short half-lives
c.
Triazolo BZs are oxidised via the cytochrome P4503A4 enzyme
d.
3-OH BZs have intermediate half-lives compared with other BZs
e.
2-keto BZs are conjugated to glucuronide radical and excreted in the urine
a
Which one of the following statements is TRUE?
In the central nervous system:
Question 11Select one:
a.
5-HT is metabolised by monoamine oxidase and catechol-o-methyltransferase
b.
5-HT is metabolised to homovanillic acid (HVA)
c.
5-HT is synthesised from tyrosine
d.
5-HT is found in neurones originating from the mid-brain raphe nuclei
e.
Release of 5-HT is partly controlled by cell body 5-HT2 autoreceptors
d
Which one of the following statements is FALSE?
Question 12Select one:
a.
Lithium reduces signal transduction by Gq-protein-coupled receptors
b.
Lithium mimics the role of Na+ in excitable tissue
c.
Lithium has a very narrow therapeutic window
d.
Chronic use of lithium is associated with hepatotoxicity
e.
Lithium inhibits IP3 turnover
Which one of the following does NOT produce drug dependence following chronic use?
Question 13Select one:
a.
Chlordiazepoxide
b.
Ethyl alcohol
c.
Cocaine
d.
Phenobarbitone
e.
Chlorpromazine
e
Concerning the basal ganglia, which one of the following statements is TRUE?
Question 14Select one:
a.
The external globus pallidus projects directly to the thalamus
b.
The putamen and thalamus together form the striatum
c.
The sub-thalamic nucleus is an integral part of the thalamus
d.
The substantia nigra zona reticulata is a major source of basal ganglia output
e.
The internal globus pallidus is the main target of cortical input
e
Which one of the following drugs would NOT be used in treatment of Alzheimer’s disease?
Question 15Select one:
a.
Piracetam
b.
Simvastatin
c.
Tacrine
d.
Selegiline
e.
Memantine
b
