Flashcards in Pharmacology of Arthritis Deck (28):
Pure analgesics such as paracetamol, have what properties?
Little anti-inflam activity
What is co-codamol made with?
Codeine and paracetamol
What type of drug is amitryptiline?
What type of drug is Gabapentin?
Give some side effects of opiod drugs?
Give some side effects of long term opiod drug use?
lack of sex drive
decreased ability to fight infection
What is the effect of NSAID on inflammation?
Symptomatic relief of inflammation but does not decrease inflammation to where the disease actually stops
Give some examples of NSAIDs?
List some side effects of NSAIDs.
dyspepsia and peptic ulcers
small/ large bowel ulceration
wheeze (avoid in asthmatics)
What is DMARDs onset of action like?
Slow acting - weeks to months
What should be given over the lag phase of DMARDs?
Do DMARDs show any analgesic effect?
How quickly should patients who present with RA be started on DMARDs?
Aim for within 3 months of symptom onset - patients do not present at the onset of symptoms
What should be given prior to starting DMARDs?
Vaccinations - flu & pneumococcal
Are DMARDs normally started individually?
No, normally methotrexate an sulphasalazine are started together
What does Methotrexate work as in the body?
How is MTX given?
Subcutaneously if GI SE of oral MTX
What conditions is MTX used in?
Give some side effects of MTX.
rash and mouth ulcers
Is MTX teratogenic?
Yes, should be stopped in males and females at least 3 months before conception
Are there any contraindications to giving MTX?
Pre-existing pulmonary fibrosis
What is sulphasalazine made of?
Azo-ester of sulphapyridine and 5-aminosalicylic acid
What is the main worrying SE of sulphasalazine?
When is hydroxychloroquin used?
What should HCQ be avoided in?
Why should azathioprine never be used with allopurinol?
Irreversible agranulocytosis occurs
In the UK, currently what is Anti-TNF licensed for?