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pharmacology and therapeutics > pharmacology of depression > Flashcards

pharmacology of depression Flashcards

1
Q

mechanism of action of sertraline

A

inhibition of serotonin reuptake results in accumulation of serotonin. serotonin in cns plays role in regulation of mood, personality and wakefulness.

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2
Q

what is the drug target of sertraline

A

serotonin reuptake transporter

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3
Q

what are the main side effects of sertraline

A

gi effects - nausea, diarrhoea, sexual dysfunction, anxiety and insomnia

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4
Q

extra info on sertraline

A

mild inhibition of dopamine transporter

must be gradually decreased on discontinuation. partial inhibition of cyp2db at high doses >150mg

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5
Q

mechanism of action of citalopram

A

inhibition of serotonin reuptake results in accumulation of serotonin. serotonin in cns plays role in regulation of mood, personality and wakefulness

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6
Q

what is target of citalopram

A

serotonin reuptake transporter

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7
Q

side effects of citalopram

A

gi effects - nausea, diarrhoea,
sexual dysfunction
anxiety
insomnia

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8
Q

extra info on citalopram

A

mild antagonism of muscarinic and histamine h1 receptors
must be gradually decreased on discontinuation
metabolised by cyp2c19

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9
Q

mechanism of action of fluoxetine

A

inhibition of serotonin reuptake results in accumulation of serotonin. serotonin plays role in regulation of mood, personality and wakefulness

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10
Q

target of fluoxetine

A

serotonin reuptake transporter

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11
Q

side effects of fluoxetine

A

gi effects - nausea, diarrhoea,
sexual dysfunction
anxiety
insomnia

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12
Q

extra info on fluoxetine

A

mild antagonism of 5ht2a and 5ht2c receptors

complete inhibition of cyp2d6 and significant inhibition of cyp2c19 - caution with warfarin

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13
Q

mechanism of action of venlafaxine

A

more potent inhibitor of serotonin reuptake than norepinephrine reuptake. noradrenaline in cns is implicated in regulation of emotions and cognition

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14
Q

targets of venlafaxine

A

serotonin transporter

noradrenaline transporter

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15
Q

side effects of venlafaxine

A

gi effects - nausea, diarrhoea

sexual dysfunction, anxiety, insomnia, hypertension (at higher doses)

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16
Q

extra info on venlafaxine

A

must be gradually decreased on discontinuation

17
Q

mechanism of action of mirtazapine

A

antagonises central presynaptic alpha 2 adrenergic receptors which causes increased release of serotonin and noradrenaline. antagonises central 5ht2 receptors, which leaves 5ht1 receptors unopposed causing anti depressant effects

18
Q

targets of mirtazapine

A

alpha 2 receptor
5 ht2 receptor
5ht3 receptor
h1 receptor

19
Q

side effects of mirtazapine

A

weight gain

sedation

20
Q

extra info on mirtazapine

A

low probability of sexual dysfunction.

may exacerbate REM sleep behaviour disorders

21
Q

why do we avoid erythromycin and citalopram

A

they prolong the qt interval

pharmacology and therapeutics (9 decks)

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