Pharmacology: Opioid Tolerance + Dependence Flashcards
1
Q
Define tolerance
A
2
Q
What is dependence?
A
3
Q
What is cross-tolerance?
A
4
Q
When can tolerance to morphine be detected?
A
5
Q
List side effects of morphine
A
6
Q
_____ side effects _____ dose escalation
A
7
Q
Mechanism of opioid tolerance
- What are opioids substrates of?
- What occurs when agonist is repeatedly stimulated?
A
8
Q
Mechanisms of opioid receptor desensitisation
A
9
Q
What is opioid-induced hyperalgesia?
A
10
Q
How can we combat opioid tolerance?
A
11
Q
Name a serious condition due to opioid tolerance + withdrawal
A
12
Q
What happens when patient withdraws after chronic administration of opioids?
A
13
Q
When are withdrawal symptoms at its climax/max + when do they disappear?
A
14
Q
What helps treat acute opioid toxicity?
A
15
Q
What helps treat withdrawal symptoms?
A
