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203: The endocrine system > Pharmacology revision > Flashcards

Flashcards in Pharmacology revision Deck (20)
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1

GH agonists example (2)

Somatropin

Mecasermin

2

GH agonist uses

Growth hormone deficiency/ Growth disorders

3

GH antagonists example and use

Pegyisomant
- Acromegaly

4

Prolactin antagonist and uses

Cabergoline
Bromocritine
Quinagolide

Use
- Hyperprolactinoma

5

ADH antagonist
- Example
- Use

Demeclocycline
- Use for SIADH

6

Thyroid agonist

Thyroxine

Tri-iodothyronine

7

Teriparatide

PTH agonist
- Use for osteoporosis

8

PTH antagonist
- Use

Cinacelcet
- Calcium receptor agonist

Treats tertiary hyperparathyroidism

9

Insulin antagonist
- And its use

Diazoxide
- Insulinoma

10

Oestrogen agonist examples and uses

Estradiol
- Menopausal hormonal replacement

Ethinylestradiol
- Female hypogonadism
- Contraception

11

Mifepristone

Progesterone antagonist
- Used for termination of pregnancy

12

Mineralocorticoid antagonist example and uses

Spironolactone
- Conn's syndrome
- Liver cirrhosis
- Severe heart failure

13

Goserlin/ Zoladex
- Drug type
- Administration
- Mechanism
- Indication
- Adverse effects

GnRH agonist
- Down regulates GnRH receptors
- Initiate increase then decreased progesterone/ testosterone

Administration
- Injection
- Non-pulsatile fashion

Indication
- Endometriosis
- Breast cancer
- Prostate cancer

Adverse effects
- Menopausal like symptoms

14

Clomifene
- Drug type
- Administration
- Mechanism
- Indication
- Adverse effects

Oestrogen receptor antagonist
- Inhibits negative feedback control of oestrogen on gonadotrophins

Indications
- Female infertility (ovarian hyperstimulation/ stimulation)

Adverse effects
- Vasomotor flushes
- Abdominal discomfort
- Visual blurring
- Cyst formation/ ovarian enlargement

15

Progesterone- only oral contraceptive
- Example
- Mechanism
- Indication
- Adverse effects

Example
- Norethisterone
- Levonorgestrel
- Desogestrel

Mechanism
-suppresses LH surge, inhibits ovulation
- Thickens cervical mucus
- Hostile endometrium

Adverse effects
- Menstrual irregularity
- Nausea
- Vomitting
- Headache

16

Somatropin
- Description
- Adverse effects

Synthetic growth hormone
- indicated for growth deficiency

Adverse effects
- Diabetes
- Hypothyroidism/ Hypopituitary
- Malignancies

17

Mecasermin

Insulin-like growth factor
- Treats growth failure in those with IGF-1 deficiency (Laron syndrome)

18

Pegvisomant

GH receptor antagonist
- Acromegaly treatment

19

Thyrotrophin

TSH
- Detects thyroid remnants and thyroid cancer

20

Oestrogen alpha receptor

Found in the hypothalamus, breast and endometrium

Tamoxifen antagonises it