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Pharmacology > Pharmacology Side Effects (reactions) > Flashcards

Pharmacology Side Effects (reactions) Flashcards

(51 cards)

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1
Q

causes coronary vasospam

A

cocaine, sumatriptan, ergot alkaloids

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2
Q

causes cutaneous flushing

A

(VANC) Vancomycin, Adenosine, Niacin, Ca2+ channel blocker

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3
Q

causes dilated cardiomyopathy

A

doxorubicin, daunorubicin

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4
Q

causes torsades de pointes

A

class III (ex: sotalol) and class IA (ex: quinidine) antiarrhymics, macrolide antibiotics, antipsychotics, TCAs

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5
Q

causes agranulocytoisis

A

Clozapine, Carbamazepine, Colchine, Propylthiouracil, Methimazole, Dapsone (Agranulocytosis Could Certainly Cause Pretty Major Damage OR Drugs CCCrush Myeloblasts & Promyelocytes)

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6
Q

causes aplastic anemia

A

Carbamezepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil (Can’t Make New Blood Cells Properly)

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7
Q

causes direct coombs positive hemolytic anemia

A

methyldopa, penicillin

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8
Q

causes gray baby syndome

A

chloramphenicol

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9
Q

causes hemolysis in G6PD-deficient patients

A

Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (Hemolysis IS D PAIN)

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10
Q

causes megaloblastic anemia

A

(females with PMS are on full BLAST mode) Phenytoin, Methotrexate, Sulfa drugs

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11
Q

Causes thrombocytopenia

A

Heparin, cimetidine

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12
Q

Causes thrombotic complications

A

OCPs like estrogen

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13
Q

Causes dry cough

A

ACE inhibitors

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14
Q

causes pulmonary fibrosis

A

Bleomycin, Amiodarone, Busulfan, Methotrexate (Breathing Air Badly from Medications)

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15
Q

causes acute cholestatic hepatits, jaundice

A

erthryomycin

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16
Q

causes focal to massive hepatic necrosis

A

Halothane, Amanita Phalloides (death cap mushroom), Valproic acid, Acetaminophen (Liver “HAVAc”)

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17
Q

causes hepatitis

A

isoniazid (INH)

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18
Q

can lead to pseudomembranous colitis

A

Clindamycin, ampicillin, cephalosporins (Antibiotics predispose to superinfection by resistant C. diff)

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19
Q

can lead to adrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

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20
Q

can causes gynecomastia

A

(Some drugs create awkward knockers) spironolactone, digitalis, cimetidine, chronic alcohol use, ketoconazole

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21
Q

causes hot flashes

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A

Tamoxifen, clomiphene

22
Q

causes hypergylcemia

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A

Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids (Taking Pills Necessitates Having Blood Checked)

23
Q

causes hypothyroidism

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A

lithium, amiodarone, suldonamides

24
Q

causes fat redistribution

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A

Protease inhibitors, Glucocorticoids (Fat PiG)

25
causes gingival hyperplasia
Phenytoin, verapamil, cyclosporine, nifedipine
26
Causes hyperuricemia (gout)
Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine (Painful Tophi and Feet Need Care)
27
Causes myopathy
fibrates, niacin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids
28
causes osteoporosis
corticosteroids, heparin
29
causes photosensitivty
Sulfonamides, Amiodarone, Tetracyclines, 5-FU (SAT For Photo)
30
causes rash/SJS
Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, pherobarbital), Allopurinol, Sulfa drugs, Penicillin (Steven Johnson has epileptic Allergy to Sulfadrugs and Penicillin)
31
Causes SLE-like syndrome (drug-induced lupus)
Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept (Having lupus is "SHIPP-E")
32
Causes teeth discoloration
tetracyclines
33
Causes tendonitis, tendon rupture, and cartilage damage
fluoroquinolones
34
causes diabetes insipidus
lithium, demeclocycline
35
Causes Fanconi syndrome
expired tetracycline
36
causes hemorrhagic cystits
Cyclophosamide, ifosfamide (Prevent by coadministering with mesna)
37
causes interstital nephritis
methicllin, NSAIDs, furosemide
38
causes SIADH
Carbamazepine, Cyclophosphamide, SSRIs (Can't Concentrate Serum Sodium)
39
causes cinchonism
Quinidine, qunine
40
Causes Parkinson-like syndome
Antipsychotics, Reserpine, Metoclopramide (Cogwheel rigidity of ARM)
41
Causes seizures
Isoniazid (vit B6 deficiency), Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (With seizures, I BITE My tongue)
42
causes tardive dyskinesia
Antipsychotics, metoclopramide
43
Cause antimuscarinic reaction
Atropine, TCA, H1-blocker, antipsychotics
44
can cause a disulfiram like reaction
Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas
45
Causes nephrotoxicity/ototoxicity
aminoglycosides, vancomycin, loop dieuetics, cisplatin
46
List cytochrome P-450 Inducers (9)
Chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine (Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs)
47
List cytochrome P-450 substrates (8)
Anti-epileptics, Antidepressants, Antipsychotics, Anesthetics, Theophylline, Warfarin, Statins, OCPs (Always, Always, Always, Always Think When Sexting Others)
48
List cytochrome P-450 inhibitors (12)
Acute alcohol abuse, Gemfirbozil, Ciprofloxacin, Isoniazid, Grapefruit juice, Quinidine, Amiodarone, Ketofonazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir (A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinnamon Rolls - used to be MAGIC RACKS in GQ)
49
List the sulfa drugs (8)
Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfsalazine, Sulfonylureas (Popular FACTSSS)
50
What can happen to patients with sulfa allergies?
Develop fever, UTIs, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urtecaria (hives). Sx range from mild to life-threatening.
51
cause direct toxicity to nerves
vincristine and paclitaxil

Pharmacology (4 decks)

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