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Flashcards in Pharmacy Deck (11)
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1
Q

Acidic drugs require an acidic environment to be absorbed, and basic drugs require a basic environment to be absorbed. True/False?

A

True

2
Q

Give 3 examples of acidic drugs

A

Penicillin
Aspirin
Phenytoin

3
Q

Give 3 examples of basic drugs

A

Diazepam
Morphine
Pethidine

4
Q

What will the absorption of penicillin be like if you take a PPI at the same time?

A

PPI remove HCl from stomach, so less acidic environment, so penicillin won’t absorb as well

5
Q

Which carrier protein binds acidic drugs?

A

Albumin

6
Q

Which carrier protein binds basic drugs?

A

Alpha-1 acid glycoprotein (A1AG)

7
Q

In the elderly, which carrier protein is higher in abundance - albumin or A1AG?

A

A1AG

Relative low albumin concn

8
Q

Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more/less lipid soluble it is.

A

Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more lipid soluble it is.

9
Q

What effect does a large Vd have on half-life of a drug?

A

Half-life of drug increases (big Vd means drug is sitting in adipose tissue)

10
Q

Give the equation for calculating the therapeutic index of a drug

A

LD50/ED50

lethal dose50)/(effective dose50

11
Q

List some drugs that have a narrow therapeutic index

A
Warfarin
Theophylline
Levothyroxine
Digoxin
Lithium
Vancomycin
Gentamicin