Phase 1 Exam

Question 1

Steps in Cell Adhesion (5)

Answer 1

Margination
Rolling
Adhesion
Transmigration
Chemotaxis

Question 2

Adhesion molecule in MARGINATION

Answer 2

NONE!

Question 3

Adhesion molecule in ROLLING

Answer 3

Selectins, Sialyl Lewis X

Question 4

Adhesion molecule in ADHESION

Answer 4

Integrins

Question 5

Adhesion molecule in TRANSMIGRATION

Answer 5

PECAM/CD31

Question 6

Adhesion molecule in CHEMOTAXIS

Answer 6

NONE!

Question 7

chemoattractant to neutrophils, monocytes,
eosinophils, and basophils; activates LOX in PMNs and
monocytes (NAGTATAWAG)

Answer 7

C5a

BARKER

Question 8

AUTOsomal DOMinant

Answer 8

Receptor/Structural Proteins

Question 9

AUTOsomal RECessive

Answer 9

Enzymes

Question 10

X-linked DOMinant

Answer 10

Only 2 usually

ALPORT syndrome
VITAMIN D Ricketssiae

Question 11

Type 1 HSN

Answer 11

ALLERGY

Question 12

Type 2 HSN

Answer 12

ANTIBODY (-mediated)

Question 13

Type 3 HSN

Answer 13

immune COMPLEX

Question 14

Type 4 HSN

Answer 14

MAST cells

Question 15

MALIGNANT nomenclature

Answer 15

Carcinoma - EPIthelial
Lymphoma - HEMATOLYMPhoid
Sarcoma - MESENchymal
HEPATOMA

Question 16

Lepromatous Leprosy is Lepromin (+) or (-)?

Answer 16

NEGATIVE because there’s no CMI

Question 17

Vitamin D Deficiency in CHILDREN

Answer 17

RICKETS

AMBULATING:
Craniotabes, , Pigeon breast
deformity (pectus carinatum), rachitic
rosary

Question 18

Vitamin D Deficiency in ADULTS

Answer 18

Osteomalacia

Question 19

Mass that crosses

midline

Answer 19

neuroBLASToma

(Sabog, lumagpas)

Wilms’ Tumor - does not cross midline. RENAL symptoms

Question 20

Atherogenesis

Answer 20

Hypercholesterolemia

Hemodynamic disturbances

Question 21

LESS PROMINENT FIBRINOID NECROSIS

Answer 21

KAWASAKI

Question 22

1-3 days of MI

Answer 22

Acute inflammation (PMNs)

Question 23

RHD

Answer 23

Aschoff bodies

Question 24

Subacute IE etiology

Answer 24

viridans streptococci
HACEK

Diseased valves

Question 25

Acute IE

Answer 25

S. aureus IV Drug users

Question 26

AML | myeloid precursors

Answer 26

neutrophils, granulocytes, platelets

Question 27

Hodgkin Lymphoma Immunophenotype

Answer 27

CD30 | CD15

Question 28

Status asthmaticus histology

Answer 28

Curschmann spirals | Charcot-LEYDEN crystals

Question 29

Keratin Pearl Formation Intercellular bridges

Answer 29

SCC (SQUAMOUS CELL) WELL-differentiated

Question 30

Signet-ring cells is associated with what type of Gastric AdenoCA

Answer 30

DIFFUSE INFILTRATIVE (Left colon) vs Intestinal (Right colon)

Question 31

Crohn's Disease Hallmark

Answer 31

SKIP lesions TRANSmural DEEP, KNIFE-like ulcers MARKED reactions Pero not TOXIC megacolon and not always MALIGNANT (if with colonic involvement lang)

Question 32

Mucosal invaginations in CHRONIC cholecystitis

Answer 32

Rokitansky-Aschoff sinuses

Question 33

CA 19-9

Answer 33

PANCREATIC CA

Question 34

CA 15-3

Answer 34

BREAST

Question 35

AFP`

Answer 35

Hepatocellular Carcinoma | Yolk-Sac Tumor

Question 36

CEA

Answer 36

Colorectal Carcinoma

Question 37

Tram-track appearance

Answer 37

MPGN (Membranous Proliferative Glomerulonephritis)

Question 38

Triad of Renal Cell Carcinoma

Answer 38

Flank Pain Hematuria Mass (Renal)

Question 39

Most common type of RCC

Answer 39

Clear Cell Carcinoma ASSOC with VHL (Von-Hippel Lindau)

Question 40

Absence of one or both testes from the scrotum

Answer 40

Cryptorchidism Krypto - hidden MC birth defect of Male GT Can it present contralaterally? YES!

Question 41

CD30

Answer 41

Embryonal Carcinoma

Question 42

PLAP

Answer 42

SEMINOMA!

Question 43

Normal PSA

Answer 43

0-4 ng/mL

Question 44

HPV genes: E7 affects?

Answer 44

Rb (TSG) --> Cellular proliferation

Question 45

HPV genes: E6 affects?

Answer 45

p53 inactivation --> activation of telomerase --> cellular immortality 5 + 3 = 8 Same sila na even number! :)

Question 46

MC malignancy of Female GT

Answer 46

Endometrial Carcinoma

Question 47

ER(+) HER2(-)

Answer 47

LUMINAL Most common Tx: Tamoxifen

Question 48

ER,PR (-/+) HER (+)

Answer 48

HER2-Enriched Tx: Trastuzumab

Question 49

ER (-) PR (-)

Answer 49

Basal (Triple Neg)

Question 50

Most common invasive cancer in humans

Answer 50

Basal Cell Carcinoma Pearly papules with telangiectasia

Question 51

Second most common tumor arising on sun-exposed sites in older people

Answer 51

Squamous Cell Carcinoma Metastases more COMMON

Question 52

Codman's triangle and Sunburst appearance is associated with

Answer 52

OSTEOSARCOMA Lace-like pattern

Question 53

Tumor of skeletal muscle differentiation

Answer 53

Sarcoma botyroides Common in young RHABDOMYOBLASTS

Question 54

Glioblastoma is characterized by? (2)

Answer 54

1. NECROSIS | 2. ENDOTHELIAL CELL PROLIFERATION

Question 55

Most common primary intraocular malignancy in children

Answer 55

RETINOBLASTOMA