phase II

Question 1

Glucoronic Acid Conjugation

Answer 1

precedes Phase II reactions

Question 2

What is Glucoronic acid conjugation

Answer 2

readily avalible in D-glucose

Question 3

Enzyme for glucoronic acid conjugation

Answer 3

UDPH Dehydrogenase

Question 4

co-enzyme that forms from glucronic acid conjugation

Answer 4

UDPGA

Question 5

O-Glucoronidation- alcohol forms a what?

Answer 5

an ether

Question 6

O- Glucoronidation- carboxylic acid forms what

Answer 6

an ester

Question 7

O Glucoronidation enzyme

Answer 7

glucouronyl transferase

Question 8

co-enzyme for O-Glucoronidation

Answer 8

UDPGA

Question 9

N-Glucorodination- WHICH AMINES?

Answer 9

Primary and secondary amines more readily form the glucuronic acid conjugates

Question 10

TERTIARY AMINE-N-Glucorodination?

Answer 10

NO

Question 11

N-Glucorodination- co-enzyme

Answer 11

UDPGA

Question 12

enzyme

Answer 12

UGT

Question 13

S-Glucorodination: thiol to what

Answer 13

thiol to thioether

Question 14

S-Glucorodination co-enzyme

Answer 14

UDPGA

Question 15

S-Glucorodination enzyme

Answer 15

UGT

Question 16

C-Glucorodination enzyme

Answer 16

UDPGA

Question 17

C-Glucorodination co-enzyme

Answer 17

glucouronyl transferase

Question 18

Sulfate Conjugation enzyme

Answer 18

sulfotransferase

Question 19

Sulfate Conjugation co-enzyme

Answer 19

PAPS

Question 20

sulfate conjugation- acts on which functional groups?

Answer 20

phenols and catechols

Question 21

Acetylation co-enzyme

Answer 21

acetyl-CoA

Question 22

Acetylation enzyme

Answer 22

acetyl transferase

Question 23

Acetylation which functional groups-?

Answer 23

primary and secondary amine, sulfonamides, and hydrazines

Question 24

Amino Acid Conjugation
functional group/ substrates

Answer 24

carboxylic acids

Question 25

Amino Acid Conjugation enzyme

Answer 25

N-acyltransferase

Question 26

Amino Acid Conjugation co-enzyme

Answer 26

the drug acts like the co-enzyme

Question 27

amino acid conjugation (where the the amino acid is the first step)

Answer 27

amino acid is the co-enzyme

Question 28

enzyme of amino acid conjugation

Answer 28

HSCOA

Question 29

methylation co-enzyme

Answer 29

SAM

Question 30

methylation enzyme

Answer 30

methyltransferase

Question 31

common substrates of methylation

Answer 31

phenols, catechols and amines

Question 32

if methylation happens on the catechol what enzyme is used

Answer 32

COMT

Question 33

if methylation happens on the amine what enzyme is used

Answer 33

N-methyl transferase

Question 34

glutathione conjugation

Answer 34

drug binds to to the thiol on the GSH and a derivative can form. this derivative is not water soluble and cannot be excreted by the body

Question 35

enzymes involved in mercaptopuric acid formation

Answer 35

γ-glutamyltranspeptidase – Cysteinylglycinase – N-acetylase

Question 36

4 electrophiles that can take part of mercaptopuric acid formation

Answer 36

Micheal acceptor imidoquinone arene oxide epoxides