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Physiology 1 Flashcards

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1
Q

Which part of the nervous system increases HR?

A

Sympathetic

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2
Q

Which part of the nervous system decreases HR?

A

Parasympathetic

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3
Q

Which nerve provides parasympathetic supply to the heart?

A

Vagus

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4
Q

Which neurotransmitter is responsible for slowing the heart rate (parasympathetic) and through which receptors?

A

Acetyl choline through

muscarinic M2 receptors

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5
Q

Which drug can be used to treat extreme bradycardia by speeding up the heart and how does it work?

A

Atropine

Competitive inhibitor of acetylcholine

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6
Q

Which neurotransmitter is responsible for increasing HR (sympathetic) and through which receptors?

A

Noradrenaline through

Beta-1 adrenoceptors

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7
Q

How does normal cardiac excitation spread through the heart?

A

SA node –> AV node –> Bundle of His –> Bundle of His left and right branches –> Purkinje fibres

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8
Q

What is stroke volume?

A

The volume of blood ejected by each ventricle per heart beat

SV = end diastolic volume (EDV) - end systolic volume (ESV)

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9
Q

What determines the cardiac preload?

A

End diastolic volume (venous return)

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10
Q

What is afterload?

A

Resistance into which the heart is pumping

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11
Q

What happens if there is a persistently increased afterload e.g. hypertension?

A

Ventricular muscle mass increases to overcome the resistance
–> ventricular hypertrophy

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12
Q

What is an inotropic effect?

A

Effect on force of contraction

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13
Q

What is a chronotropic effect?

A

Effect on heart rate

e.g. positive chronotropic effect = increases HR

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14
Q

What is cardiac output and how is it calculated?

A

The volume of blood pumped by each ventricle per minute

CO = SV x HR

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15
Q

When do normal heart valves produce a sound?

A

When they shut

not normally when they open

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16
Q

What are the 5 stages of the cardiac cycle?

A
  1. Passive filling
  2. Atrial contraction
  3. Ventricular contraction
  4. Ventricular ejection
  5. Ventricular relaxation
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17
Q

What produces the first heart sound?

A

When the ventricular pressure exceeds atrial pressure, the AV valves shut (mitral and tricuspid)

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18
Q

What produces the second heart sound?

A

After ventricular ejection, when the ventricular pressure falls below the aortic/pulmonary pressure –> aortic and pulmonary valves shut

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19
Q

Where does S1 fall in systole and diastole?

A

Beginning of systole

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20
Q

Where does S2 fall in systole and diastole?

A

End of systole/beginning of diastole

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21
Q

What does the P wave represent on an ECG?

A

Atrial depolarisation

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22
Q

What does the QRS complex represent on an ECG?

Study These Flashcards
A

Ventricular depolarisation

23
Q

What does the T wave represent on an ECG?

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A

Ventricular repolarisation

24
Q

Which part of the ECG represents ventricular contraction (systole)?

25
Which part of the ECG represents ventricular relaxation (diastole)?
TP segment
26
What does the PR interval represent?
AV nodal delay
27
How do you calculate rate on an ECG?
300/number of large squares between beats
28
Which lead is usually used as the rhythm strip?
Lead 2
29
What are the 6 steps to describing an ECG?
1. Verify patient details 2. Check date and time ECG was taken 3. Check calibration of paper 4. Determine axis 5. Work out rate and rhythm 6. Look at individual leads for voltage criteria or ST/T-wave changes
30
Which 7 questions should you address when looking at rate/rhythm on an ECG?
1. Is electrical activity present? 2. Is the rhythm regular or irregular? 3. What is the heart rate? 4. Are P-waves present? 5. What is the PR interval? 6. Is each P-wave followed by a QRS complex? 7. Is the QRS duration normal?
31
What is a normal PR interval?
0.12 - 0.20 seconds
32
How is mean arterial pressure (MAP) calculated?
MAP = ( (2 x diastolic pressure) + systolic pressure ) / 3
33
What is normal MAP?
70 - 105 mmHg
34
What is the minimum MAP required to perfuse coronary arteries, brain and kidneys?
60 mmHg
35
How does MAP relate to CO?
MAP = CO x SVR (systemic vascular resistance)
36
Which vessels are responsible for creating systemic vascular resistance?
Arterioles
37
Which mechanism is responsible for moment-to-moment regulation of PB e.g. prevention of postural changes?
Baroreceptors Reflex
38
What results from a failed baroreceptor response and how is it defined?
Postural (orthostatic) hypotension Drop in BP within 3 mins of standing from lying: - systolic at least 20 mmHg (with or without symptoms) - diastolic at least 10 mmHg (with symptoms)
39
What is the principle of long term control of blood pressure?
Control of blood volume via | Extra-cellular fluid volume
40
Which 2 main factors affect extracellular fluid volume?
Water excess or deficit | Sodium excess or deficit
41
Which hormones regular extracellular fluid volume?
1. Renin-Angiotensin-Aldosterone System (RAAS) 2. Natriuretic peptides 3. Antidiuretic hormone (vasopressin)
42
Which two key factors does RAAS affect in the regulation of MAP?
Plasma volume | Systemic vascular resistance
43
Describe the RAAS
- renin released from kidneys, stimulates formation of angiotensin I in the blood from angiotensinogen (produced by liver) - angiotensin I is covered to angiotensin II by ACE - angiotensin II has 3 effects: 1. stimulates release of aldosterone from adrenal cortex 2. causes systemic vasoconstriction --> increases SVR 3. Stimulates thirst and ADH release --> increases plasma volume - Aldosterone acts on kidneys to increase sodium and water retention --> increases plasma volume
44
Where is ACE produced?
Pulmonary vascular endothelium
45
Where is renin released from?
Granular cells in juxtoglomerular apparatus of kidney
46
Which 3 mechanisms stimulate renin release?
- renal artery hypotension - stimulation of renal sympathetic nerves - decreased sodium in renal tubular fluid
47
Which hormones provide a counter-regulatory system for the RAAS?
Natriuretic peptides (NPs)
48
How do NPs work?
- cause excretion of salt and water - decrease renin release - act as vasodilators - -> decrease BP
49
What are the type types of NPs?
ANP | BNP
50
Which hormone can be measured in patients with suspected HF?
Serum BNP
51
Where is ADH synthesised and stored?
Synthesised in hypothalamus | Stored in posterior pituitary
52
What is the main stimulus for ADH secretion?
Increased plasma osmolality
53
How does ADH work?
Acts in kidney tubules to increase reabsorption of water | --> increase plasma volume/BP

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