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GK F3E4 > Pituitary 3 > Flashcards

Pituitary 3 Flashcards

1
Q

5 physiologic functions of PRL (prolactin)

A
  1. Milk production
  2. Steroidogensis in adrenals
  3. Metabolism of fats/carbs
  4. Vit D metabolism
  5. Fetal development
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2
Q

2 main functions of PRL?

A
  • Mammary gland development (puberty)
  • Initiation of lactation post-partum (pregnancy)
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3
Q

PRL is secreted by what?

Where are they secreted?

What is the manner?

A
  • Lactotrophs
  • Anterior pituitary
  • Pulsatile
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4
Q

PRL is inhibited by what??

A

Prolactin Inhibitory Factor

(Dopamine)

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5
Q

PRL is stimulated by what??

A

High Thyrotropin Releasing Hormone

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6
Q

PRL is increased by what 2 things?

Smaller increases occur w/ what 6 things?

A
  • CW motion & nipple stimulation
  1. After sleep
  2. Exercise
  3. Intercourse
  4. Stress
  5. Pregnancy
  6. Lactation
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7
Q

PRL suppresses which 3 hormones?

Suppression of this hormone leads to what sxs?

A
  • Gonadotropin Releasing Hormone (GnRH)
  • LH and FSH are lowered too as result
  • –> altered menses & fertility
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8
Q

PRL stimulates adrenal androgen production leading to what 2 sxs?

A
  • Weight gain
  • Hirsuitism (esp women)
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9
Q

What are 4 S/S of Hyperprolactinemia in ONLY women?

A

◦Irregular menstruation

◦Menopausal symptoms

◦Weight gain

◦Signs of increased androgens (hirsuitism)

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10
Q

What are 2 S/S of Hyperprolactinemia in ONLY men?

A

◦Impotence

◦Gynecomastia

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11
Q

What are S/S of Hyperprolactinemia in BOTH men/women?

A
  • Infertility
  • HA
  • Loss of libido
  • Peripheral Vision Problems
  • Moods changes/ depression
  • Galactorrhea
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12
Q

What 2 sxs are indicative of MACROadenoma when PRL levels are elevated?

A
  • HA & Vision Changes
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13
Q

Fasting Serum Prolactin Levels should be measured in ALL pts w/ what 3 sxs?

A
  • galactorrhea
  • gynecomastia
  • hypogonadism
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14
Q

What does “further work up” for Hyperprolactinemia entail?

A

MRI (with or without contrast)

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15
Q

What are some causes of Hyperprolactinemia?

A

}Prolactinoma (autonomous production)

}Other pituitary tumors (GH, ACTH)

}Hypothalamic disease

}Chronic Kidney Failure (decreased clearance by kidneys)

}Cirrhosis or Liver Disease

}Spinal cord damage

}Chest wall injury (such as in herpes zoster or surgery)

}Severe Primary Hypothyroidism (high TRH)

}Anti-psychotic medications

}Radiation, Surgery

}Idiopathic

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16
Q

1st and 2nd MC cause of Pituitary Adenomas?

Least common?

A
  1. PRL (40-45%)
  2. GH (20%)

LC: TSH (1-2%)

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17
Q

What type of PRL level if above 200 is HIGHY suggestive of a PRL secreting adenoma?

A

Basal (fasting serum) PRL level

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18
Q

What types of adenomas are MC in men vs women?

A

Women: MICROadenomas

Men: MACROadenomas

(Women are smaller than men)

19
Q

90% of women w/ hyperprolactinemia have what 3 sxs?

A
  • Amenorrhea
  • Glactorrhea
  • Infertility

(GIA)

20
Q

Men c/o what 5 sxs most commonly w/ hyperprolactinemia?

A
  • dec. libido
  • HA
  • vision changes
  • impotence
  • infertility

(men need an ID to get HIV checked)

21
Q
  • Medications may cause hyperprolactinemia w/ PRL levels at what range?
  • Which drugs? (try to remember 7)
A
  • ≤50-100 ng/mL
  • Dopamine-receptor “antagonists” (1st gen. anti-psychotics and Reglan)

Dopamine-”depleting” agents (methyldopa, reserpine)

Others (INH, danazol, tricyclic antidepressants, verapamil, estrogens, antiandrogens, cyproheptadine, opiates, H2-blockers)

22
Q

Work up for Hyperprolactinemia:

  • H&P
  • identify autonomous prolactinoma / other etiologies
  • Serum assays (which 8?)
  • MRI of which 2 structures?
  • Visual field exam (if mass suspected)
  • Neuro testing (if mass effect suspected)
A
  1. Fasting PRL
  2. FSH
  3. LH
  4. Estradiol
  5. Tesosterone
  6. TSH
  7. Renal/Hepatic
  8. HCG (in females)
  • Pituitary & Brain MRI
23
Q

T/F

  • MOST microadenomas DO NOT progress to macroadenomas
24
Q

T/F

  • Most macroprolactinomas DO NOT require therapy?
A

False,

  • Dopamine agonists: Bromocriptine twice daily w/ food
  • +/- surgical resection
25
3 tx options for Prolactinemia & Prolactinoma
* Transsphenoidal resection * Surgical resection * Radiation therapy
26
**Definition:** * Inability to lactate
Hypoprolactinemia
27
**Hypoprolactinemia** * Lactotrophs are at risk for what 2 things (esp w/ what comorbidity)
Infarction & Necrosis (HTN)
28
**Hypoprolactinemia** * What is post-partum hemorrhage called? * Pts w/ which comorbidity are more susceptivle to Post-partum pituitary infarction?
* Sheehan's Syndrome * Diabetics
29
What is the Autoimmune Destruction associated w/ Hypoprolactinemia?
* Lymphocytic Hypophysitis
30
What test is used for Hypoprolactinemia? What are the results which would be +?
**Stimulation test:** ◦Administration of TRH (chlorpromazine and others) ◦Rise in PRL levels \<200% = Hypoprolactinemia
31
**Functions of ADH** * Synthesized where? * Secreted by what? * Increase in serum osmolarity or a decrease in intravascular volume
* Hypothalamus * Posterior Pituitary Gland
32
**Abnormalities in ADH** * Absent/too little/receptor issues w/ ADH leads to what? * Too much ADH leads to what?
* **Too little:** Diabetes Insipidus * **Too much:** SIADH
33
2 types of DI?
* Central / Neurogenic (rare) * Nephrogenic
34
MC etiology of Neurogenic/Central DI?
Idiopathic (30%)
35
2nd MC etiology of Neurogenic/Central DI?
**Tumors (25%)** ◦Primary (gliomas, craniopharyngiomas) ◦Secondary (lung cancer, breast cancer, leukemia or lymphoma) ◦Pituitary or Hypothalamus
36
3 lesser common etiologies of Neurogenic/Central DI from greates to least?
1. **Neurosurgery** 2. **Trauma** 3. **Familial disease** (defect in gene that codes for ADH precursor)
37
MC cause of Nephrogenic DI?
Lithium (20%)
38
Which 2 etiologies of Nephrogenic DI block the action of ADH?
}Hypercalcemia and/or hypokalemia
39
**Which etiology of Nephrogenic DI?** ◦Defective expression of ADH receptors or aquaporin-2
Congenital / Hereditary
40
3 diseases which cause Nephrogenic DI?
Sickle cell disease, PCKD, pyelonephritis
41
**Nephrogenic or Neuro/Central DI?** * relatively common * Almost all patients: elderly, sick,
Nephro
42
Both Nephro and Neuro DI have what sxs?
◦\*New onset nocturia in the absence of drinking before sleep or prostatic enlargement (in men over age 50)
43
**S/S of DI** * Frequent passage of large volumes of dilute urine * Excessive/intense thirst (predilection for cold or iced drinks) * Increased fluid ingestion * 24 hour urine volumes range from ___ to ___ L
2.5 - 20 L!!!
44
**Clinical Manifestations of DI** * Water balance maintained IF thirst intact & adequate ingestion of fluid * IF access to water is interrupted, the pt may develop what??
**Hypertonic volume depletion:** * _CNS manifestations:_ * irritability * mental dullness * coma

GK F3E4 (12 decks)

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