Pituitary agents

Question 1

Drugs Affecting Anterior Pituitary Hormones

Answer 1

• Growth hormone agonists: replaces human GH and stimulate growth
  - Ex: somatropin (Nutropin, Saizen, Humatrope)
• Growth hormone antagonists: acts directly on postsynaptic dopamine receptors in the brain to inhibit GH secretion
  - Ex: bromocriptine (Parlodel), octreotide (Sandostatin)

Question 2

Drugs affecting posterior pituitary hormones

Answer 2

actions: antidiuretic action on kidneys
uses: treating diabetes insipidus and hemophilia A
ex: cornivaptan (Vaprisol), desmopressin (DDAVP, Stimate, tolvaptan (Samsca)