Pituitary Disease Flashcards
(20 cards)
sign of low ACTH
panhypopituitary
loss of pigmentation
sign of low FSH/LH
oligomenorrhoea
hypogonadism
sign of low prolactin
failure of lactation
sign of low ADH
diabetes insipidus
polyuria
polydispsia
prolactinoma sizes and gender
younger women <10mm
men and elderly women >10mm
signs and symptoms of prolactinoma
galactorrhoea amenorrhoea hypogonadism erectile dysfunction arrested puberty stimulates milk production inhibits HnRH and gonadotropin production
size of GH secreting tumour
mm-cm
signs and symptoms of GH secreting tumour
change in appearance
increase height
acromegaly/gigantism
size of ACTH secreting tumour
majority <10mm
signs and symptoms of ACTH secreting tumour
Cushing’s syndrome
size of TSH secreting tumour
> 10mm
S+S of TSH secreting tumour
hyperthyroidism
size of non-functioning tumour
most >10mm @ presentation
signs and symptoms of non functioning tumour
hypopituitarism
mechanical S+S
list the causes of a non-functioning large pituitary adenoma
compression bitemporal hemianopia (optic chiasm) ocular palsies (CN II,IV,VI) and diplopia hypopituitarism signs of increase ICP (headache) hypothalamic: hunger, thirst, sleep ventricles and sphenoid sinuses
list the causes of a functioning large pituitary adenoma
acromegaly
hyperprolactinaemia
cushings
mass effects
what is acromegaly?
excress GH that stimulates skeletal and soft tissue growth
causes of acromegaly?
pituitary tumour in most cases
paraneoplastic release of GH from non-pit tumours
S+S of acromegaly
increase hand/foot size sweating large tongue HTN prominent supraorbital ridge protruding mandible interdental separation poor libido symptoms of DM, hypopituitarism visual deterioation
diagnosis of acromegaly
HIGH IGF-1
GTT: glucose >2mcg/ml @ hours
(normal = suppression of glucose)
