PK5 Flashcards
(5 cards)
1
Q
What factors would explain species/breed differences in absorption?
A
GIT anatomy
Skin structure
2
Q
How might metabolism vary between species?
A
Huge genetic variability in the cytochrome P450 enzymes that facilitate these metabolic processes
Some differences in capacity to do certain chemical reactions between species
3
Q
Why difference in metabolism processes can be dangerous?
A
Diff species have diff reactions which can lead to increased toxic metaboites created. e.g. cats and paracetamol
4
Q
Why is renal excretion in urine less species specific than drug metabolism?
A
Excretion is passive
5
Q
Look at examples of breed difference onthe lecture
A
