PKPD Spring E1

Question 1

Debrisoquine

Enzyme, Genetic Variability

Answer 1

CYP2D6

Question 2

Metoprolol

Enzyme, Genetic Variability

Answer 2

CYP2D6

Question 3

Encainide

Enzyme, Genetic Variability

Answer 3

CYP2D6

Question 4

Imipramine

Enzyme, Genetic Variability

Answer 4

CYP2D6

Question 5

Nortriptyline

Enzyme, Genetic Variability

Answer 5

CYP2D6

Question 6

Maprotiline

Enzyme, Genetic Variability

Answer 6

CYP2D6

Question 7

Hydralazine

Enzyme, Genetic Variability

Answer 7

N-acetyltransferase NAT 2

Question 8

Procainamide

Enzyme, Genetic Variability

Answer 8

N-acetyltransferase NAT 2

Question 9

Isoniazid

Enzyme, Genetic Variability

Answer 9

N-acetyltransferase NAT 2

Question 10

Mercaptopurine

Enzyme, Genetic Variability

Answer 10

Thiopurine S-methyltransferase (TPMT)

Question 11

Azathioprine

Enzyme, Genetic Variability

Answer 11

Thiopurine S-methyltransferase (TPMT)

Question 12

Warfarin

Enzyme, Genetic Variability

Answer 12

CYP2C9

Question 13

Omeprazole

Enzyme, Genetic Variability

Answer 13

CYP2C19

Question 14

Esomeprazole

Enzyme, Genetic Variability

Answer 14

CYP2C19

Question 15

Lansoprazole

Enzyme, Genetic Variability

Answer 15

CYP2C19

Question 16

Pantoprazole

Enzyme, Genetic Variability

Answer 16

CYP2C19

Question 17

Rabeprazole

Enzyme, Genetic Variability

Answer 17

CYP2C19

Question 18

Irinotecan

Enzyme, Genetic Variability

Answer 18

Urine diphosphate glucuronyl transferase

Question 19

Drugs that were FDA recalled because sex-related ADE with OT prolongation

Answer 19

CATTG - cat ate the triple gecko

Cisapride
Astemizole
Terfensadine
Troglitazone
Grepaflozacin