Placenta and Fetal Membranes Flashcards

(41 cards)

1
Q

What is the decidua basalis? Where is it located?

A
  • the part of the endometrium that participates with the chorion in the formation of the placenta
  • is at the site of implantation
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2
Q

What is the decidua capsularis? Where is it located?

A
  • it grows over embryo in luminal side, encapsulating it
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3
Q

What is the decidua parietalis? Where is it located?

A
  • membrane lining the main cavity of uterus everywhere other than at site of attachment of the chorion
  • on the opposite uterine wall to basalis/capsularis
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4
Q

When does implantation normally occur?

A

Late second week, approximately 10 days post-fertilization

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5
Q

What does the trophoblast differentiate into? What are each layer?

A
  • cytotrophoblast (inner layer)

- syncytiotrophoblast (outer layer)

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6
Q

What are signs and symptoms of an ectopic pregnancy? (4)

A
  • abdominal pain
  • amenorrhea
  • vaginal bleeding
  • rupture of oviduct wall
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7
Q

What is the chorionic sac comprised of? (3)

A
  • extraembryonic somatic mesoderm
  • cytotrophoblasts
  • syncytiotrophoblasts
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8
Q

What is the amnion?

A

The thin, tough membrane that surrounds the embryo/fetus and amniotic fluid

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9
Q

How does the amnion develop?

A

amnioblasts separate from the epiblast and enclose the developing amniotic cavity

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10
Q

What is the purpose of amniotic fluid? (3)

A
  • cushions fetus
  • permits fetal movements
  • regulates fetal body temperature
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11
Q

What is hydramnios? What can cause it? (3)

A
  • excessive amniotic fluid
  • a genetic defect
  • fetal defect in CNS
  • blockage of GI tube
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12
Q

What is oligohydramnios? What can cause it? (2)

A
  • insufficient amniotic fluid
  • placental abnormality
  • maternal high blood pressure
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13
Q

What can oligohydramnios cause? Why?

A
  • renal agenesis
  • pulmonary hypoplasia
  • Because decreased fluid doesn’t provide enough cushion to fetus and umbilical cord
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14
Q

What is the amniochorionic membrane?

A

fusion of the amniotic sac and chorionic sac that occurs when amniotic sac grows faster than the C.S.

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15
Q

What are the two components of the placenta?

A
  • villous chorion (fetal part)

- decidual basalis (maternal part)

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16
Q

How is the smooth chorion formed?

A

chorion that is in contact with the decidua capsularis undergoes atrophy so that villi die and it becomes smooth

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17
Q

How do the chorionic villi attach to the decidua basalis?

A

Attach through the cytotrophoblastic shell

18
Q

How is the placenta formed? (3)

A
  • cytotrophoblasts (CTBs) of chorionic villi proliferate at chorionic plate
  • CTB’s extend through syncytiotrophoblasts, forming cytotrophoblastic shell
  • shell attaches to and erodes decidua basalis, creating intervillous space
19
Q

What are cotyledons?

A

Irregular convex areas of villous chorion

20
Q

What do cotyledons contain? (2)

A
  • 2+ main stem villi

- multiple branch villi

21
Q

What are main stem villi?

A

Villi that extend from the chorionic plate

22
Q

What are branch villi? What is their purpose?

A
  • Villi that extend from a main stem villus

- increase villus surface area

23
Q

What is an anchoring villi?

A

Villi that attach to maternal tissues through cytotrophoblastic shell

24
Q

What can cross the placenta? (6)

A
  • nutrients
  • hormones
  • IgG antibodies (maternal defense for baby)
  • waste products
  • drugs
  • infectious agents
25
What does not cross the placenta? (3)
- protein hormones - bacteria - drugs w/amino acid-like structures
26
What runs through the umbilical cord, vessel-wise? (2)
- two umbilical arteries (deoxygenated blood) | - one umbilical vein (oxygenated blood)
27
What is placenta previa?
When the placenta implants in the lower part of the uterus or in the cervix
28
What can placenta previa lead to?
Dangerous 3rd trimester bleeding
29
What is placenta accreta?
Partial or complete absence of the decidua
30
What can placenta accreta lead to? Why?
- Severe postpartum bleeding | - The villous chorion adheres directly to the myometrium and placenta fails to separate at birth
31
What is a hydatiform mole?
replacement of normal villi by dilated or hydropic translucent vesicles
32
What are hydatiform moles caused by?
polyspermy or duplication of a single sperm
33
What is a partial mole? what is it caused by?
- growth of tissue when a normal ovum fertilized by two sperm
34
What is a complete mole caused by? What tissue does it lack?
- When an empty egg is fertilized and contains only paternal DNA from either two sperm or duplication of a single sperm - contains no fetal tissue
35
What is an invasive mole? How is it treated?
- A complete mole that penetrates or perforates the uterine wall - Is responsive to chemotherapy
36
What is a gestational choriocarcinoma?
highly invasive metastatic tumor that arises from trophoblast
37
How is gestational choriocarcinoma diagnosed?
By seeing increasing hCG titer with no uterine enlargement
38
What is the treatment for gestational choriocarcinoma?
Combined chemotherapy agents
39
What are dizygotic twins?
Aka 'fraternal twins', they originate from two zygotes and have two separate implantations (so separate chorions and amnions
40
What are monozygotic twins?
Aka 'identical twins', they originate from one zygote, and can have variable membranes depending on when they divide - the earlier they divide, the more separate the membranes and placentas will be!
41
How do monozygotic twins form, most often?
By division of the embryoblast of the blastocyst