Placental Hormones Flashcards Preview

HR MVST 1b > Placental Hormones > Flashcards

Flashcards in Placental Hormones Deck (14):
1

Expression, effect, predictor for
hCG

STB peak in 1st trimester
maternal recognition of pregnancy
high in molar pregnancies
Short-term luteal support (maintains corpus luteum)
Vasodil uterine vasc
Hyperglycosylated from from EVT --> autocrine of more EVT and spiral artery conversion
STIM:
Oestrogen and activin a
INHIBIT:
Progesterone and inhibin a
After 6-7w placental steroids take over

2

Expression, effect, predictor for
hPL

STB 2nd to 3rd trimester
Conc rises as hCG conc drops
appetite stimulant, lipolysis so increased FFAs
stim growth of mammary gland tissue
STB

3

Expression, effect, predictor for
PGH

Placental growth hormone
STB throughout pregnancy
Antagonises peripheral insulin
Lipolysis
Gluconeogenesis
Replaces (suppresses) maternal pituitary GH
STB and EVT

4

Expression, effect, predictor for
Leptin

STB peaks end of 2nd/beginning of 3rd trimester
Appetite stimulant
Stimulates placental transporter expression
STB and maternal adipose
Regulated by hCG and oestrogen

5

Expression, effect, predictor for
PAPP-A

STB increases throughout pregnancy
Low levels at end of first trimester indicate aneuploidy or IUGR
Cleaves IGFBP
Stim local growth and proliferation

6

Expression, effect, predictor for
progesterone

STB throughout pregnancy
Maintains uterine queiscence
appetite stimulant
maintains endometrium, immunomodulator
levels indicate size of placenta
Produced by ovary until 12-16w
Late preg initiate parturition, initiate lactation,m increase growth uterus and mammary glands

7

Expression, effect, predictor for
oestrogens

STB and fetal liver/adrenal increases throughout pregnancy
Maternal circulation --> cholesterol --> placenta --> pregnolone --> etus --> adrenal sulfonates to make insoluble 16-OH DHEAS and protect females against masculinisation --> placenta --> desulfates to androgens --> oestrogens --> maternal circulation
Maintains pregnancy
Oestriol 16alpha levels correlate with fetal health
Constant decline over several days indicates a need to induce pregnancy
Increase uterine blood flow and angiogenesis

8

CRH

Placenta makes
As well as oestrogen stim adrenal cortex to make cortisol and aldosterone ---> leads to retain water and salt --> increase blood volume by 40% to match dilated maternal circulation

9

Relaxin

Protein hormone
Sec by corpus luteum, placenta, decidua
Vasodil in early pregnancy
Softens ligaments and cervix in late pregnancy, increases dimensions birth canal

10

Prolactin

Stim by ACTH oestrogen MSH
Produced by maternal pituitary and decidua NOT PLACENTA
Growth mammary glands
Potentiates LH and FSH action?

11

Which hormones are appetite stimulants?

HPL
Leptin (?)
Progesterone

12

Which hormones cause vasodilation?

hCG
Relaxin

13

Which hormones lead to mammary growth?

hPL
Progesterone
Prolactin

14

PAI-2

Decreases fibrinolysis so increases risk of thromboembolism 5-6x
From placenta