Plama Cell Disorders

Question 1

Plasma cell disorders are monoclonal neoplasm from the

Answer 1

B-lymphocyte lineage

Question 2

Examples of plasma cell disorders

Answer 2

Multiple myeloma
Waldenstrom macroglobulinemia
Primary amyloidosis

Question 3

Clinical manifestations of all the plasma cell disorder relate to

Answer 3

1. Expansion of the neoplastic cells
2. Secretion of cell products (immunoglobulin molecules or subunits, lymphokines)
3. Host response to the tumor

Question 4

In most plasma cells, light chains are cleared by the kidney

Answer 4

Light chains are excreted per day
<10 mg

Question 5

Immunoelectrophoresis

Answer 5

Qualitative assessment of M component

Question 6

Electrophoresis

Answer 6

Quantitative assessment of the M Component

Question 7

Monoclonal antibody must be present at

Answer 7

Concentration of Atleast 5 g per liter to be accurately quantitated by electrophoretic analysis

Question 8

Amount of M component in the serum

Answer 8

Reliable measure of tumor burden

Excellent tumor marker to manage therapy

Not specific enough to be used to screen asymptomatic patients

Question 9

Rare skin diseases associated with with a monoclonal gammopathy

Answer 9

Lichen myxedematosus aka papular mucinosis

Necrobiotic xanthogranuloma

Question 10

Papular mucinosis aka lichen myxedematosus

Answer 10

Highly cationic IgG is deposited in the dermis of patients

Question 11

Necrobiotic xanthogranuloma

Answer 11

Is a histiocytic infiltration of the skin usually face

Produces red or yellow nodules that can enlarge to plaques

Question 12

Light chains are secreted in the urine as

Answer 12

Bence Jones Protein

Question 13

IgG myelomas are more common than IgA and IgD myelomas

Answer 13

True