Plasma Clotting Defects

Question 1

What is characteristic of Hemophilia A?

Answer 1

Factor VIII (8) deficiency
20%-30% spontaneous mutation
85% of all hemophilias

Question 2

What is characteristic of Hemophilia B?

Answer 2

Factor IX deficiency (9)
Recessive sex linked disease
10% of Hemophilias

Question 3

What test do we use to differentiate between Hemophilia A and B?

Answer 3

APTT
1:10 dilution
VIII for Hemo A
IX for Hemo B

Question 4

How do we treat Hemophilia A?

Answer 4

Cryoprecipitate (Fibrinogen, VIII, and vWF)
Factors VIII and IX

Question 5

How can we treat Hemophilia B?

Answer 5

Prothrombin complex
Factors II, VII, IX, and X
Factor IX concentrates

Question 6

What do patients run the risk of developing when we administer treatments for hemophilia A and B?

Answer 6

Inhibitors or antibodies to their infusion products

Question 7

What is another name for Factor XIII?

Answer 7

Transglutaminase

Question 8

What do we see in patients with Factor XIII deficiency?

Answer 8

Poor wound healing
Keloid Scarring
Umbilical cord bleeding
Prolonged bleeding