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CLINICAL CHEMISTRY > PLASMA PROTEINS > Flashcards

PLASMA PROTEINS Flashcards

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1
Q

-also known as tranthyretin
-binds retinol and thyroxine

A

pre-albumin

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2
Q

sensitive marker of poor nutritional status
half life: 2 days

A

prealbumin

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3
Q

plasma protein that has a greater concentration in the CSF than in plasma

A

prealbumin

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4
Q

most abundant protein in the blood
main transport protein

A

albumin

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5
Q

plasma protein that is a major contributor to oncotic pressure

A

albumin

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6
Q

plasma protein:

assessment of nutritional status
half life: 17-21 days

A

albumin

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7
Q

plasma protein:

has the highest binding capacity
most anodal protein

A

albumin

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8
Q

this is used in cases with hemolytic anemia as it contraindicates Hba1c

A

fructosamine

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9
Q

fructosamine is also known as?

A

glycated albumin

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10
Q

plasma protein:

neutralizes trypsin and elastase

A

alpha-1-antitrypsin

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11
Q

deficiency in a1-antitrypsin results to? (2)

A

juvenile cirrhosis
pulmonary emphysema

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12
Q

plasma protein:

also known as orosomucoid

A

a1-acid glycoprotein

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13
Q

plasma protein:

transports progesterone

A

a1-acid glycoprotein

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14
Q

plasma protein:

a principal fetal antigen and an oncofetal antigen

A

a1-fetoprotein

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15
Q

plasma protein:

in amniotic fluid
decrease in a1-fetoprotein is a marker of -

A

trisomy 21/18

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16
Q

plasma protein:

in amniotic fluid
increase in a1-fetoprotein is a marker of -

A

neural tube defect/spina bifida

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17
Q

plasma protein:

in adults a1-fetoprotein is a marker for (2)

A

hepatocellular carcinoma
testicular cancer/gonondal cancer

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18
Q

plasma protein:

binds free hgb

A

haptoglobin

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19
Q

determine the hemolysis

decreased: haptoglobin
decreased: hemopexin

A

intravascular hemolysis

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20
Q

what kind of poikilocyte is seen in cases of intravascular hemolysis

A

schistocytes

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21
Q

determine what kind of hemolysis

normal: haptoglobin
decreased: hemopexin

A

extravascular hemolysis

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22
Q

what kind of poikilocyte is seen in extravascular hemolysis

A

spherocytes

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23
Q

plasma protein:

transports coppers

A

ceruloplasmin

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24
Q

a disease that is associated with

cerulosplamin deficiency
decreased in production

A

wilson’s disease

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25
a disease that is associated with copper deficiency decrease in absorption
menke’s disease
26
determine the disease serum ceruloplasmin: decreased serum copper: decreased copper deposits: present
wilson’s disease
27
determine the disease serum ceruloplasmin: decreased serum copper: decreased copper deposits: absent
menke’s disease
28
a disease that causes kayser flescher rings
wilson’s disease
29
a disease that has an appearance of kinky hair
menke’s disease
30
plasma protein: largest non-immunoglobulin protein
a2-macroglobulin
31
plasma protein: increases 10x in nephrotic syndrome
a2-macroglobulin
32
plasma protein: also known as siderophilin transports iron
transferrin
33
plasma protein: negative acute phase reactants (3)
prealbumin albumin transferrin
34
plasma protein: binds heme decreased in both intravascular and extravascular hemolysis
hemopexin
35
plasma protein: essential in immune response, what is the most abundant
complement, C3
36
plasma protein: precursor of fibrin clot seen in plasma not in serum causes band
fibrinogen
37
plasma protein: major acute phase reactant functions as opsonin in associated with increase risk in CAD
c-reactive-protein
38
plasma protein: sensitive but non specific increases 1000x in cases of inflammation/injury
c-reactive protein
39
plasma protein: produced by the plasma cells protects from antigens
immunoglobulins/ antibodies
40
most abundant immunoglobulin
igG
41
most largest immunoglobulin
igM
42
old name of immunoglobulins
gammaglobulins
43
plasma proteins are synthesized in
liver
44
made up of amino acids linked through peptide bonds
proteins
45
proteins in presence of ammonia causes degradation converting to - which is excreted in urine
urea
46
these are released at site of injury that causes liver to increase acute phase reactants
cytokines
47
can predict the risk of premature birth
fibronectin
48
protein determination method: routine method requires 2 peptide bonds and alkaline medium purple colored complex measured at 540nm
biuret method
49
protein determination method: classic method reference method
kjeldahl method
50
protein determination method: involves digestion of protein and measurement of its nitrogen content
kjeldahl method
51
protein determination method: utilized UV method
direct optical method
52
protein determination method: direct optimal methods 210nm: -
peptide bonds
53
protein determination method: direct optimal method 280nm: -
amino acids: TRYYPTOPHAN
54
protein determination method: for albumin determination
dye-binding technique
55
protein determination for albumin bromcresol -: common
bromcresol green
56
protein determination for albumin bromcresol -: most specific, sensitive and precise
bromcresol purple
57
serum protein electrophoresis: a1: increased a2: increased b: increased
acute inflammation immediate response
58
serum protein electrophoresis: y: increased
chronic inflammation delayed response
59
serum protein electrophoresis: a1 flat curve
pulmonary emphysema juvenile cirrhosis
60
serum protein electrophoresis: b-y bridging
hepatic cirrhosis
61
serum protein electrophoresis: increased production of fast migrating immunoglobulin
hepatic cirrhosis
62
serum protein electrophoresis: a2 strike
nephrotic syndrome
63
serum protein electrophoresis: a2, b: increased
nephrotic syndrome
64
serum protein electrophoresis: monoclonal gammopathy gamma spike
multiple myeloma
65
serum protein electrophoresis: gamma spike in IgM
waldenstrom macroglubulinemia
66
in presence of gamma spike in serum electoprhoresis it should be followed by?
immunofixation electrophoresis
67
presence of a narrow band in the beta region may be due to the presence of
fibrinogen
68
fibrinogen may cause a narrow band in what region
beta
69
this may cause blip pattern in late a2 or early b region due to presence of free hgb
hemolysis
70
hemolysis may cause blip in what region of serum electrophoresis
late a2 early b
71
small blip in a2 region may be due to
hemoglobin-haptoglobin complex
72
hemoglobin-haptoglobin complexes may cause a blip at what region
a2
73
used to detect oligoclonal bands that are found in the gamma region
CSF electrophoresis
74
Urine electrophoresis: albumin: strong
glomerular proteinuria
75
urine electrophoresis: a1,a2,b: strong
tubular proteinuria
76
urine electrophoresis: monoclonal light chains
overflow proteinuria
77
presence of monoclonal light chains in urine electrophoresis could mean overflow proteinuria what proteins are present
bence jones proteins

CLINICAL CHEMISTRY (1 decks)

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