Platelet Rich Plasma Flashcards
Which of the following is common clin application for PRP therapy?
1. hip joint contracture
2. shoulder adhesive capsulitis
3. patellar tendinopathy
4. femoral fx
- patellar tendinopathy
In general, what is treatment goal of PRP therapy in ortho and sports med?
1. treat pts with thrombocytopenia
2. increase pt med expenses
3. improve bone mineral density
4. foster soft tissue repair
- foster soft tissue repair
what is the function of platelets
angiogenesis, inflammatory process, cell proliferation, release GF and cytokines
*responsible for hemostatic activity
Normal platelet numbers
150k-400k/uL
What is PRp?
derivative of whole blood, contains platelet concentrations 2-3x more than normal
has GF, EGF, VEGF, PDFG, FGF, IFG
*growth factors help with tissue healing
right now, PRP is used for
ortho procedures
cardio surgery
sports injuries
plastic surgery
gynecology
urology
med esthetics
PRPs initiate ___ and release of _____
tissue repair
release of active factors (GF, cytokines, lysosomes)
release of adhesion proteins for healing
what are treatment goals of PRP?
modulate pain, foster tissue repair (jump start healing in chronic inj, accelerate repair in acute)
true or false: PRP is well standardized
false: poorly standardized prep methods and diff opinions on best blood component concentrations
what are clin applications of PRP?
dentist stuff (maxiollofacial/peridontal disease)
-MSK/tissue regeneration from sports injury
-TENDON INJURIES
-medical esthetics
-regenerative plastic surgyer
-diabetic foot ulcers
-intrauterine infusion in women for IVF
what does evidence suggest for PRP?
-safe
-inconsistent outcomes, questionable efficacy
-pts respond diff due to diff immune responses, meds, demographics
-long term effects unknown
what are challenges with PRP?
-unfamiliar to many Drs.
-ped pop use is minimal
-not accessible/affordable
-scarce research
strongest evidence for PRP in rehab is with
knee OA
maybe wound healing
***clear roles for restoring tendon structure (PT)
