Platelets Flashcards
(23 cards)
RR for platelet count
150,000-400,000/mm³
what does the platelets help initiate
the coagulation cascade
<50,000 or >1 million are the clinical values for what count?
platelets count
platelets are integral to
hemostasis
high platelets levels
can be associated with increase clotting risk
what type of platelet count in needed to maintain vascular integrity
5 to 10 thousand
30-50k platelet count
moderately increased risk of bleeding
10-30k platelet count
severely increased risk of bleeding (don’t transfuse plt unless bleeding-but not common)
less than 10k platelet count you should _____ because the bleeding risk is _______
transfuse, severely increased risk
what is considered an increased platelet level
greater than 400,000 suggest malignancy Polycythemia vera Postsplenectomy syndrome Drugs
if a patient shows signs of
Polycythemia vera
Postsplenectomy syndrome what would you consider?
an increased platelet level
what drugs can cause an increased platelet level
testosterone
estrogen
oral contraceptives
conditions associated with Thrombocytopenia
Leukemia
Cirrhosis
DIC (disseminated intravascular coagulation)
Anemia
which types of anemia are associated with Thrombocytopenia
Hemolytic
Pernicious
Thrombocytopenia types, which is more rare
ITP (Idiopathic Thrombocytopenic Purpura)
TTP (Thrombotic Thrombocytopenic Purpura
TTP is rare
what platelet count is associated with Thrombocytopenia
a decreased level <100,000/mm3
ITP is more common
children and AIDS patients
the prognosis is better in children
ITP etiology
Autoimmune
Patient develops antibodies against their own platelets
where does massive phagocytosis of platelet-antibody immune complexes occur in ITP
the spleen
ITP presentation history
Pt usually asymptomatic EXCEPT for mucosal & skin bleeding due to decreased platelets
Pt may have had antecedent viral infection
a patient presents with petechiae, purpura, epistaxis, menorrhagia what would you consider for a diagnosis?
ITP
a patients labs come back with Platelet count markedly low, usu. < 10,000 (10)
but other blood counts & peripheral smear normal, what would you consider for a diagnosis?
ITP
treatment and prognosis for. ITP
Usu. self-limited in children
In adults prescribe corticosteroids
If unresponsive to medical therapy, possible splenectomy
50-60% will develop chronic ITP
