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Pharmacology > PNS Receptors > Flashcards

PNS Receptors Flashcards

(42 cards)

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1
Q

M2
Tissue
Response
Mechanism

A

Tissue - heart and axon terminals (auto receptors)
Response - decreases HR, conduction velocity, and contractility (opposite of beta 1 and 2).
Mechanism - Gi, increased K efflux, decreased Ca influx

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2
Q

M3 Tissues of action

A

Smooth muscle, secretory glands, and vascular endothelium

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3
Q

M3 action on smooth muscle
Types of smooth muscle
Response
Mechanism

A

Eye, bronchioles, GI tract, urogenital system
Response - contraction
Mechanism - Gq

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4
Q

M3 action on secretory glands
Response
Mechanism

A

Response - increased secretion

Mechanism - Gq

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5
Q

M3 action on vascular endothelium
Response
Mechanism

A

Response - vasodilation

Mechanism - Ca++/CaM activates eNOS → ↑ NO → ↑ cGMP → relaxation

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6
Q

Nm
Tissue
Response
Mechanism

A

Tissue - NMJ
Response - skeletal muscle contraction
Mechanism - Na/K channel opens –> depolarization

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7
Q

Nn tissues of action

A

Atuonomic ganglia and adrenal medulla

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8
Q

Nn action on autonomic ganglia
Response
Mechanism

A

Response - depolarizes postsynaptic neurons

Mechanism - opens Na/K pump –> depolarization

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9
Q

Nn action on adrenal medulla
Response
Mechanism

A

Response - depolarizes medullary cells –> secretion of catecholamines
Mechanism - opens Na/K pump –> depolarization

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10
Q

Alpha 1 tissues of action

A

smooth muscle (eye, vascular, urogenital, and hair follicles), and liver

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11
Q

Alpha 1 action on smooth muscle
Types
Response
Mechanism

A

eye, vascular, urogenital, hair follicles
Response - contracts smooth muscle
Mechanism - Gq

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12
Q

Alpha 1 action on liver
Response
Mechanism

A

Response - increased glycogenolysis and gluconeogenesis

Mechanism - Gq

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13
Q

Alpha 2 tissues of action

A

Axon terminals (autoreceptors), pancreatic beta cells, vascular smooth muscle, platelets

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14
Q

Alpha 2 action on axon terminals
Response
Mechanism

A

Response - decreased NE release
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++

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15
Q

Alpha 2 action on pancreatic beta cells
Response
Mechanism

A

Response - decreased insulin release
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++

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16
Q

Alpha 2 action on vascular smooth muscle
Response
Mechanism

A

Response - contracts smooth muscle
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++

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17
Q

Alpha 2 action on platelets
Response
Mechanism

Study These Flashcards
A

Response - aggregation
Mechanism - Gi and Gq. ↓ AC → ↓ cAMP; ↑ K+ channel efflux; ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++

18
Q

Beta 1 tissues of action

Study These Flashcards
A

Heart and kidney (JG cells)

19
Q

Beta 1 action on heart
Response
Mechanism

Study These Flashcards
A

Response - increased HR, conduction velocity, and contractility (opposite as M2)
Mechanism - Gs: ↑ AC → ↑ cAMP → ↑ PKA → ↑ L-type Ca++ channel influx
Beta1 predominate in heart 100:1 compared to beta2

20
Q

Beta 1 action on kidney
Response
Mechanism

Study These Flashcards
A 
Response - JG cells secrete more renin
Ang II (via renin release) --> vasoconstriction
Mechanism - Gs: ↑ AC → ↑ cAMP → ↑ PKA → ↑ L-type Ca++ channel influx
21
Q

Beta 2 tissues of action

Study These Flashcards
A

SM (eye, bronchioles, GI, urogenital, vascular), heart, liver, skeletal muscle, pancreatic beta cells

22
Q

Beta 2 action on SM
Types
Response
Mechanism

Study These Flashcards
A

Types - eye, bronchioles, GI, urogenital, vascular
Response - relaxes smooth muscle
Mechanism - Gs: ↑ AC → ↑ cAMP; in smooth muscle, inhibits MLCK → ↓ myosin-PO4 → relaxation

23
Q

Beta 2 action on heart
Response
Mechanism

Study These Flashcards
A

Response - increase HR and contractility

Mechanism - ↑ AC → ↑ cAMP

24
Q

Beta 2 action on liver / skeletal muscle
Response
Mechanism

Study These Flashcards
A

Response - increased glycogenolysis and GNG (liver)

Mechanism - ↑ AC → ↑ cAMP; in smooth muscle, inhibits MLCK → ↓ myosin-PO4 → relaxation

25
Beta 2 action on pancreatic beta cells Response Mechanism
Response - increased insulin release | Mechanism - ↑ AC → ↑ cAMP; in smooth muscle, inhibits MLCK → ↓ myosin-PO4 → relaxation
26
D1 Tissues Response Mechanism
Tissues - vascular SM, especially renal Response - vasodilation --> increased GFR Mechanism - Gs
27
D2 Tissues Response Mechanism
Tissues - Axon terminals (autoreceptors) and cholinergic neurons in gut Response - Decrease DA release and GI motility (via inhibited Ach release) Mechanism - Gi: ↓ AC → ↓ cAMP; ↑ K+ efflux; ↓ Ca++ influx
28
Pupil diameter
M3 → iris circular muscle contraction → miosis (smaller) B2 → circular muscle relaxation → mydriasis (larger) A1 → iris radial muscle contraction → mydriasis
29
Lens shape
M3 → ciliary muscle contraction (relaxes ligament) → accommodation (more round) B2 → ciliary muscle relaxation → flattens lens
30
Lacrimal glands
M3 → tear secretion
31
Bronchial smooth muscle
M3 → bronchoconstriction. B2 → bronchodilation | Blocking M3 and stimulating B2 aids in COPD / asthma
32
Bronchial glands
M3 → mucous secretion. B2 → water secretion via CFTR
33
Heart
M2 → Gi → close funny Na channels → decreased SA / AV node conductivity → bradycardia and decreased atrial contractility. Acts via vagus nerve. B1 & 2 → Gs → cAMP opens Ca channels → increased SA / AV node automaticity / conductivity → tachycardia
34
Vascular system
* M3 → relaxes endothelial cells → decreased BP * A1 & 2 → SM constriction → increased BP * A1 are #1 control of increasing vascular resistance. * B2 → vasodilation in liver & skeletal muscle → increased flow * D1 → dilation of renal arteries / arterioles → increased flow
35
Intestine
* M3 → contraction of circular / longitudinal muscles → peristalsis * A1 & B2 → relaxation of intestinal muscles → decreased peristalsis * Hyperpolarizatoin / relaxation caused by activation of Ca-dependent K channels
36
GI sphincters
* M3 → relaxation → increased motility | * A1 → contraction → decreased motility
37
GI secretions
* M3 → increased acid secretion from parietal cells, increased intestinal secretions, and gall bladder contraction * B2 → decreased acid secretion, increased gall bladder relaxation, but increased amylase secretion
38
Kidney / Bladder
* D1 → vasodilation → increased GFR * B1 → renin release from JG cells * M3 → contracts detrusor, relaxes trigone & sphincter → urination * B2 → relax detrusor → urinary retention * A1 → constricts trigone & sphincter → urinary retention
39
Penis
* M3 → vasodilation → erection (parasympathetic) | * A1 → contracts seminal vesicles, prostatic capsule, and vas deferens → ejaculation (sympathetic)
40
Uterus
* B2 → uterus relaxation * A1 → uterus contraction * M3 → uterus contraction
41
General secretions
* M3 → watery secretions from salivary, nasopharyngeal, pulmonary, GI, and eccrine sweat glands (used for temp control). * A1 → viscous salivary secretions and apocrine sweat glands (axilla and groin)
42
Metabolism
* A2 → decreased insulin release from pancreatic beta cells * B2 → increased insulin release, glycogenolysis & GNG in liver, glycogenolysis & K+ uptake in skeletal muscle. Good for fight / flight.

Pharmacology (6 decks)

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