Polycystic Kidney Disease

Question 1

Tolvaptan

Answer 1

V2 receptor antagonist
Induce polyuria
Contraindicated in liver impairment and pt with poor oral intake
Starting dose 45mg mane and 15mg 8 hours later
Max dose 90mg mane and 30mg later
Aim serum osmol <280

Question 2

Which is the most important prognostic sign for ADPKD to progress to ESKD

Answer 2

Increase in cysts size

Question 3

PKD most associated with

Answer 3

Hepatic cyst

Occurring up in 50-70%

Question 4

Diagnosis in those with family hx

Answer 4

15-39 - 3 cysts in total
40-59 - 2 cysts in each kidney
>60 - 4 cysts in each kidney