Polynuclear aromatic Hydrocarbons Flashcards Preview

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Flashcards in Polynuclear aromatic Hydrocarbons Deck (4)
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1
Q

Characteristics ?

A

Powerful carcinogens
Skin cancer
Oxidation –> Epoxide
Some are Mutagenic

2
Q

Powerful carcinogens ?

A

Benzopyrene
Phenanthrene
Cholanthrene Derivatives
–> Skin cancer and sarcomas (subcutaneously)

3
Q

Direct acting Carcinogens ?

A

Nitrogen mustard
Methyl nitrosurea
–> can react with DNA
–> Polycyclic must be metabolized before (Enzymes in the Body (Liver))

4
Q

Epoxide

A

very reactive electrophilic groups –> React with the negative center of the DNA

  • -> BUT normally they are rapidly hydrolyzed into Hydroxyl groups
  • -> coupled to GLUCURONIC acid –> Urine