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Population Genetics Flashcards Preview

Kaplan Biochem and Genetics > Population Genetics > Flashcards

Flashcards in Population Genetics Deck (8)
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1

cystic fibrosis has a heterozygous resistance to

typhoid fever

2

hemochromatosis has a heterozygote advantage in

an iron-poor environment

3

Glucose 6P dehydrogenase deficiency and the resulting hemolytic anemia has a heterozygote resistance to

malaria

4

sickle cell disease has a heterozygous resistance to

malaria

5

Siblings share what % of their genes

1/2 (50%)

6

1st cousins share what percentage of their genes?

1/8

7

2nd cousins share what percentage of their genes?

1/32

8

Hardy-Weinberg equilibrium

- p(squared) + 2pq + q(squared) = 1
- p and q are the allele frequencies at a locus
- allows calculations of carrier frequency and prevalence of genetic disease
- For AR diseases:
- p (squared) = homozygous normal
- 2pq = heterozygous carrier
- q (squared) = homoqygous affected
* when calculating allele frequency, remember that p + q = 1

Decks in Kaplan Biochem and Genetics Class (21):

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