Potassium-sparing diuretics

Question 1

MoA

Answer 1

Promotes urination (diuresis) without the loss of potassium.
Inhibits sodium channels in the distal convoluted tubule.
Weak diuretics - typically used as an adjunct to Loop/Thiazide diuretics.

Question 2

Examples

Answer 2

Amiloride
Triamterene (urine looks blue in some lights)

Question 3

Indication

Answer 3

Given with thiazide or loop diuretics as a more effective alternative to potassium supplements.
Preferred choice to counteract hypokalaemia

Question 4

Side effects

Answer 4

Hyperkalaemia

Question 5

Interactions

Answer 5

Other drugs which cause hyperkalaemia

Avoid concomitant ACEi/ARB, K+ supplements and aldosterone antagonists.