Powders (Exam 3)

Question 1

powders

Answer 1

mixture of dry, finely divided drugs/chemicals
external or internal use

Question 2

drugs have a __________ onset of action due to ___________

Answer 2

rapid

disintegration not being required

Question 3

powders can _____________ upon standing

Answer 3

cake or harden

Question 4

label for external powders

Answer 4

external use only

Question 5

powders are primary ingredients for most other delivery systems such as

Answer 5

solid dosage forms
liquid dosage forms
semisolids

Question 6

per se medicated powders

Answer 6

bulk powders (internal/external)
divided powders (internal)

Question 7

divided medicated powders

Answer 7

doses of powders divided into individual packets
active ingredient and inert diluent
more precise dosing

Question 8

oral bulk medicated powders are measured

Answer 8

volumetrically using measuring spoons or cups and mixed with liquid

Question 9

oral bulk medicated powders are reserved for

Answer 9

non-potent drugs

Question 10

oral bulk medicated powders are not used for drugs that

Answer 10

require precise and accurate dosing

Question 11

mix divided medicated powders with __________ before swallowing

Answer 11

liquid vehicle

Question 12

bulk volume =

Answer 12

true volume(intermolecular space) + porosity

Question 13

bulk density

Answer 13

volume of given was of powder, space between powder and porosity of particles

Question 14

tapped density

Answer 14

packed volume of a given mass of particles under a well defined rate and extent of agitation

Question 15

true density

Answer 15

density of solid particle alone

Question 16

powder flow is a product of

Answer 16

the strength of cohesive forces of a powder

Question 17

factors affecting flow properties of powders

Answer 17

shape and size

Question 18

powders with a low angle of respose flow

Answer 18

freely

Question 19

powders with a high angle of repose flow

Answer 19

poorly

Question 20

angle of repose

Answer 20

tan(angle) = height of cone/radius of cone

Question 21

how to measure spherical particles

Answer 21

particle diameter

Question 22

how to measure irregular shaped particles

Answer 22

equivalent spherical diameter (area/volume are the same)

Question 23

sieve analysis

Answer 23

particles passed by mechanical shaking through series of screens of decreasing size

Question 24

microscopy

Answer 24

direct technique to determine particle size
uses calibrated grid background

Question 25

light scattering

Answer 25

most popular analysis of diffracted light as a laser passes through particles

Question 26

the reduction of particle size is accompanied by

Answer 26

great increase in surface area of solids

Question 27

how to reduce particle size

Answer 27

trituration levigation pulverization by intervention

Question 28

trituration

Answer 28

grind powder with mortar and pestle

Question 29

levigation

Answer 29

powder is mixed with viscous liquid

Question 30

pulverization by intervention

Answer 30

used with hard crystalline or gummy type substances that do not crush or triturate easily

Question 31

spatulation

Answer 31

use a spatula blend powders by moving spatula through them on a slab

Question 32

spatulation is not suitable for

Answer 32

large quantities of powder mixtures containing potent substances

Question 33

trituration is more suitable for

Answer 33

mixtures containing small quantities of drugs

Question 34

geometric dilution

Answer 34

small amount of drug mix with large amount of diluent

Question 35

sifting

Answer 35

passing powders through sifters NO POTENT DRUGS

Question 36

tumbling

Answer 36

powder blenders or mixers large scale production

Question 37

internal bulk powders are labeled with

Answer 37

the weight of active ingredient per volume to be administered

Question 38

bulk powders contain ____________ substances

Answer 38

nonpotent

Question 39

another name for divided powders

Answer 39

chartulae

Question 40

when preparing divided powders, prepare enough powder for

Answer 40

one extra dosage unit

Question 41

when preparing divided powders, if a small amount of powder is used,

Answer 41

add a small amount of diluent

Question 42

powder paper for volatile components

Answer 42

glassine waxed paper

Question 43

powder papers for non-volatile components

Answer 43

simple bond paper

Question 44

powder papers with limited moisture resistance

Answer 44

vegetable parchment glassine

Question 45

waterproof powdered paper

Answer 45

waxed paper

Question 46

hygroscopic powder

Answer 46

absorb moisture from the air

Question 47

deliquescent powder

Answer 47

absorb moisture and dissolve to form solution

Question 48

aerosol powders

Answer 48

particle size 1-6 um inert propellants and diluents are added to aid in flow properties and uniformity