PPNP 2 - skin conditions

Question 1

Drugs for skin urticaria

Answer 1

Antihistamines (2nd gen)
- loratidine
- fexofenadine

Corticosteroids

Question 2

Drugs for cellulitis

Answer 2

Beta lactam cephalosporin
- Cephalexin (PO)

Protein synthesis inhibitor lincosamide
- Clindamycin (PO)

Question 3

Cephalexin MOA

Answer 3

Inhibit bacterial cell wall synthesis

Broad spectrum (both +/-)

Question 4

Cephalexin effects

Answer 4

Rash, diarrhea

Thrombophlebitis

Question 5

Clindamycin MOA

Answer 5

protein synthesis inhibition

• affect 50s subunit of bacterial ribosome
• broad spectrum (+/-, anaerobes, MRSA)

Question 6

Clindamycin effects

Answer 6

GI, headache, anaphylaxis, constipation, superinfection, myopathy, pseudomembranous colitis

Question 7

Drugs to test ulcers

Answer 7

Beta lactam
- Piperacilin-tazobactam

2nd gen fluroquinolones
- Ciprofloxacin

Lincosamide
- Clindamycin

Glycopeptide
- Vancomycin

Question 8

Piperacilin-tazobactam MOA

Answer 8

Inhibits cell wall synthesis (transpeptidation)

Extended spectrum (pseudomonal)

Question 9

Piperacilin-tazobactam effects

Answer 9

rash, diarrhea, thrombophlebitis

Question 10

Vancomycin Moa

Answer 10

inhibit cell wall synthesis (transglycosylation)

• in dividing gram +
• for serious MRSA

Question 11

vancomycin effects

Answer 11

N/V, anaphylaxis, superinfection, nephrotoxicity, ototoxicity, Red Man’s syndrome