Practice Exam NAPLEX #1 (Access Pharmacy) Flashcards by Thu Pham

Vaccines are available against which bacteria that cause meningitis?

S. pneumoniae
H. influenzae,
N. meningitidis

How well did you know this?

Not at all

Perfectly

SIADH is caused by what underlying disorder and common cause?

Euvolemic hypotonic hyponatremia & sertraline

How well did you know this?

Not at all

Perfectly

Prozac is available in what dosage forms?

Once daily capsules
Oral solution
Weekly capsule

How well did you know this?

Not at all

Perfectly

mEq Calcium concentration from lowest to highest

Gluconate 90 mg
Acetate 250 mg
Carbonate 400 mg

How well did you know this?

Not at all

Perfectly

Bisphosphonates in order from lowest available dosage (mg per tablet) to highest.

Risedronate
Alendronate
Ibandronate

How well did you know this?

Not at all

Perfectly

What is the recommended type of screening is done annually for lung cancer?

Helical CT scan

How well did you know this?

Not at all

Perfectly

What is considered a stand alone ASCVD risk-enhancing factor?

HIV

How well did you know this?

Not at all

Perfectly

What medications may interact with medicinal doses of garlic?

Metoprolol
Oral contraceptives
Rilpivirine
Fentanyl

How well did you know this?

Not at all

Perfectly

By what MOA does glucagon reverse beta-blocker induced hypotension and bradycardia?

Stimulation of the glucagon receptors on the beta-receptor complex

How well did you know this?

Not at all

Perfectly

What laboratory parameters need to be checked prior to starting Lithium?

Serum creatinine
Electrocardiogram
Thyroid function tests
Electrolytes

How well did you know this?

Not at all

Perfectly

What would be a contraindication to administration of tamoxifen for the prevention of breast cancer in a “high risk” premenopausal patient?

History of deep venous thrombosis “DVT”

How well did you know this?

Not at all

Perfectly

Tumor lysis syndrome (TLS) prevention and management for a newly diagnosed patient with acute lymphocytic leukemia (ALL).

Initiate allopurinol
Treating electrolyte disturbances
Aggressive hydration

How well did you know this?

Not at all

Perfectly

What is the most common side effect of ondansetron?

Constipation and headache

How well did you know this?

Not at all

Perfectly

Risk factors associated with melanoma AE:

Presence of multiple dysplastic nevi
Presence of genetic factors
Individuals with fair skin type who sunburns easily
Individuals who are immunosuppressed

How well did you know this?

Not at all

Perfectly

What is a safe option for treatment of postmenopausal osteoporosis that does not have any restrictions in renal impairment?

Calcitonin

How well did you know this?

Not at all

Perfectly

What is the total calcium requirement for a pregnant woman?

1000 - 1300 mg daily

How well did you know this?

Not at all

Perfectly

Important counseling point for Migranal (dihydroergotamine)

Once prepared, use within 8 hours.

Nasal spray

How well did you know this?

Not at all

Perfectly

What adjunctive measures is used to lessen the occurrence of nephrotoxicity associated with amphotericin B?

Normal saline boluses

How well did you know this?

Not at all

Perfectly

Females weighing more than 198 lbs should have no issues using what contraceptives?

Depo-Provera (causes wt gain)
NuvaRing
Yasmin

Xulane is not recommended in patient > 198 lbs

How well did you know this?

Not at all

Perfectly

What percentage of total calories is provided by the fat content?

10%

fats provide 9 kcal/g

How well did you know this?

Not at all

Perfectly

What was the main requirement of the Poison Prevention and Packaging Act?

Reducing the oral-prescription medication death rates in children under 5 yoa

How well did you know this?

Not at all

Perfectly

Parkinson Disease drugs in order according to ability to control motor symptoms (bradykinesia, rigidity, tremor) from most efficacious to least

Carbidopa/levodopa
Amantadine IR
Rasagiline
Ropinirole

How well did you know this?

Not at all

Perfectly

What monoclonal antibodies used in the treatment of colorectal cancer is associated with causing hypomagnesemia?

Panitumumab & Cetuximab

How well did you know this?

Not at all

Perfectly

What adverse events should be discussed prior to first cycle infusion of rituximab?

Hep B reactivation
Infusion related reactions
Tumor lysis syndrome
Flu-like symptoms

How well did you know this?

Not at all

Perfectly

What common oral iron formulation contains 20% of elemental iron?

Ferrous sulfate 60 mg per 5 ml syrup

What measure of central tendency should be utilize for primary outcome for nominal data?

Mode

What is the best recommended oral contraceptive for a patient with premenstrual dysphoric disorder (PMDD)?

YAZ is FDA approved for PMDD

What oral contraceptives are FDA approved for acne treatment?

Ortho Tri-Cyclen & Estrostep

Side effects associated with interferon

1. Flu-like symptoms requiring premedication with antipyretic 2. Fatigue 3. Depression 4. Somnolence and confusion

Side effects associated with oral evening primrose oil use

Overall, evening primrose oil is well tolerated with some GI side effects (abdominal pain, N/V/D, flatulence, dyspepsia)

What type of pharmacoeconomic analysis assumes the outcomes are equal?

Cost-minimization *measures cost in dollars and outcomes equal

What is the percentage error of the inaccurate balance equation?

Error x 100% / Desired Quantity

List the disease that requires the least total number of doses of penicillin to the least most.

1. Secondary syphilis 2. Late Latent syphilis 3. Neurosyphilis

Define intent to treat (ITT)

The analysis includes all participants in the arm to which they were randomized originally

What is a potential adverse effect when using oral antihistamines for the management of allergic rhinitis in a 3 yo child?

Paradoxical agitation

What is a potential adverse effect related to intranasal corticosteroids?

HPA axis suppression

What is an adverse effect related to overuse of topical decongestants?

Rebound congestion

What patient population or condition often leads to fast titration of antipsychotic drugs (ASDs)?

Children *because they require prompt control of seizures to avoid interference with brain development and cognition*

What is an important counseling point for Humira?

Proper injection technique *SQ and available as a single-dose syringe or pen device*

What agents have been associated with osteonecrosis of the jaw?

Teriparatide Alendronate Denosumab

What data pertaining to prostate cancer screening is reviewed to determine diagnosis?

DRE and PSA combined

Neutrophils function/role

To engulf and destroy the infectious pathogen

What is the best empiric regimen against C. glabrata?

Caspofungin 70 mg x 1 dose, then 50 mg daily

What type of biological safety cabinet (BSC) should the cytarabine be prepared in?

Vertical flow, class II *HEPA filtered air "ISO class 5" is required for personnel in handling hazardous agents)

Counseling point for capecitabine

Take tablets with food

What natural products could increase the risk of bleed with concomitant warfarin use due to the supplement's antiplatelet/anticoagulant properties?

1. Chondroitin & glucosamine sulfate 2. Evening primrose oil 3. Garlic 4. High doses of fish oil

What medical condition may be exacerbated when receiving bevacizumab?

Hypertension

Counsel points when starting metoprolol

1. Hypotension 2. Bradycardia 3. SOB

What is the recommended duration of a COC before changing products?

3 months

What agent has been associated with liver toxicity and failure, and its use is contraindicated in patients with pre-existing liver disease in Parkinson Disease?

Tolcapone

What is considered the gold standard for measurement of GFR?

Insulin clearance

Which insulin can be mixed with insulin glargine in one syringe in order to decrease daily insulin injections?

None

Which insulins can be mixed with insulin NPH?

Insulin aspart and insulin regular

What therapy should be administered within 1 hour of the recognition of sepsis?

Broad-spectrum antimicrobial therapy

What patient groups are considered to have complicated UTIs?

1. Children 2. Men 3. Pregnant women 4. Catheter-associated

What agent should be utilized in patients with castration-resistant prostate cancer with bone pain for assistance with pain reduction?

Radium-223

Main adverse effect about lamotrigine

rash

What agents can cause constriction of the afferent arteriole?

1. Tacrolimus 2. Ibuprofen 3. Cyclosporine

Counseling point when ibuprofen and aspirin is being taking

Take ibuprofen at least 30 minutes after aspirin or aspirin 8 hours after ibuprofen. Monitor BP often

What is the pretreatment for paclitaxel infusion to prevent infusion reactions?

1. Dexamethasone 2. Ranitidine 3. Diphenhydramine

Why is folic acid recommended along with methotrexate therapy?

Folic acid can prevent GI toxicity caused by MTX.

What TNF-inhibitors can be self-administered SQ?

Cimzia and Humira

Unfractionated heparin routes of administration

IV and SQ

What is the primary therapy for early stage colon cancers?

Surgery

What is the best treatment option for a 61 yoM who is chemotherapy naive and was recently diagnosed with extensive-stage small-cell lung cancer?

Cisplatin + Etoposide + Atezolizumab

Counseling tips for someone starting levothyroxine for hypothyroidism

1. Levothyroxine will need to be continued lifelong 2. Should be taken OES 3. Separated at least 4 hours from other medications

What IV vasodilator therapies would be contraindicated in a pregnant patient with ADHF?

Enalaprilat *ACE-I*

What agent best targets the symptoms of rhinorrhea?

Ipratropium

What classes of medication can be used for management of allergic rhinitis after the first trimester of pregnancy?

1. Oral antihistamines (cetirizine/levocetirizine) 2. Intranasal corticosteroids (budesonide) 3. Oral decongestants (not during 1st trimester) 4. Topical decongestants (safer option)

What is the duration of antimicrobial therapy in most patients with septic shock?

7-10 days

List the NNRTIs in order based upon initial starting dose (lowest to highest)

1. Rilpivirine 2. Nevirapine 3. Etravirine 4. Efavirenz

What agent is FDA indicated for social anxiety disorder and can be used first-line?

Effexor XR (venlafaxine XR)

What medications contains tenofovir alafenamide (taf)?

1. Odefsey (Emtricitabine, rilpivirine, tenofovir-taf) | 2. Genvoya )Elvitegravir, cobicistat, emtricitabine, tenofovir-taf)

What class of antihypertensive overdose is bradycardia, hypotension and hyperglycemia hallmarks of toxicity?

Calcium channel blockers

What agents are utilized in the prophylactic management for PJP and Toxoplasmosis?

Atovaquone, dapsone and leucovorin

What is the most commonly utilized agent in the management of PJP and Toxoplasmosis?

SMZ/TMP

What is the appropriate dose of ondansetron to prevent PONV?

4 mg IV given at the end of surgery

MOA of isoniazid

Inhibition of mycolic acid production which is necessary for mycobacterial cell walls

MOA of ethambutol

Inhibition of mycobacterial arabinosyl transferase to inhibit cell wall production

MOA of rifamycins

Inhibition of DNA-dependent RNA polymerase in bacterial cells

Rank the glaucoma eye drops from highest to lowest ability to lower IOP

1. Latanoprost (35%) 2. Timolol (30%) 3. Brinzolamide (26%) 4. Brimonidine (18%)

When should a serum digoxin concentration be obtained at least __ hours, but preferably _____ hours following last dose?

At least 6 hours but preferably 12-24 hours after last dose

What is used for empiric treatment of a moderate-severe, polymicrobial cellulitis?

Ertapenem 1 g IV daily *Broad-spectrum: covers S. aureus, streptococci, Gram-negatives, anaerobes. NO Pseudomonas*

What is the appropriate BUD for a Mini Bag Plus product assembled in the LAFW under proper conditions as part of batch?

BUD assignment of the assembled system does not apply. As with proprietary products, expiration date is assigned based on manufacturer's recommendations.

Hyperkalemia may result from AKI and can lead to what life-threatening complications?

Arrhythmias

Practice Exam NAPLEX #1 (Access Pharmacy) Flashcards

(85 cards)