preclinical studies Flashcards
1
Q
mice chosen for anxiety model
A
- mice prefer dark enclosed spaces
- plus shaped enclosure
2
Q
preclinical studies
A
- important foundation in drug development pipeline
3
Q
legal requirements for preclinical studies
A
- US federal laws require non-human animal research to occur to show safety and efficacy of new treatments
- efficacy is the ability to produce a desired or intended result
4
Q
translational medicine
A
- category of biomedical research
- aims to improve human health
5
Q
principles of animal research
A
- research must be justified
- animals must be treated with respect/care
- it is highly regulated
3 R’s principles in animal research
- replacement; computer models, invertebrates instead of vertebrates
- reduction; fewer animals
- refinement; improved experimental design, minimize pain and distress
6
Q
ACVR1 signalling pathway
A
- cell surface receptor
- responds to ligand
- cascade turns on downstream genes
- mutation in the kinase domain; creates mutant ACVR1 protein with different signalling properties
7
Q
ALS
A
- progressive and fatal
- causes motor neurons to break down
- drug development involved preclinical models
