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Pregnancy Dermatoses > pregnancy dermatoses > Flashcards

pregnancy dermatoses Flashcards

1
Q

autoimmune bullous dermatosis of pregnancy; typically seen 2nd or 3rd trimester
starts periumbilical

A

pemphigoid gestationis (Herpes gestationis)

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2
Q

autoantibody in pemphigoid gestationis (Herpes gestationis)

A

BPAG2 (180kDa, NC16A site)

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3
Q

when can you see flares of pemphigoid gestationis (Herpes gestationis)

A

with delivery
OCPs
menses

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4
Q

pemphigoid gestationis (Herpes gestationis) pts have increased risk of…

A

graves dz

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5
Q

how to differentiate pemphigoid gestationis (Herpes gestationis) from PUPPP

A

DIF!

see linear C3 at BMZ

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6
Q

level of split + histology of pemphigoid gestationis (Herpes gestationis)

A

subepidermal (BPAG2 target) with eos, necrotic keratinocytes

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7
Q

SSS binding side of pemphigoid gestationis (Herpes gestationis)

A

epidermal

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8
Q

risk to fetus with pemphigoid gestationis (Herpes gestationis)

A

prematurity, SGA

up to 10% with skin involvement

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9
Q

HLAs a/w pemphigoid gestationis (Herpes gestationis)

A

DR3 and DR4

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10
Q

what predisposes to PUPPP

A

1st pregnancy
twins
maternal obesity

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11
Q

PUPPP distribution

A

within striae and SPARES periumbilical area

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12
Q

PUPPP and risk to fetus

A

none

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13
Q

excoriates papules and sometimes pustules over extensor surfaces, usually no bullae

A

prurigo of pregnancy

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14
Q

generalized pruritus in pregnancy worst at night and on trunk/plams/soles

A

cholestasis of pregnancy

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15
Q

labs to check with cholestasis of pregnancy

A

serum bile acids (if > 40, high risk for fetus)

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16
Q

treatment for cholestasis of pregnancy

A

ursodeoxycholic acid

17
Q

pustules on erythematous base initially in intertriginous areas in pregancy

A

pustular psoriasis of pregancy (aka impetigo herpetiformis)

18
Q

risk to fetus with pustular psoriasis of pregancy (aka impetigo herpetiformis)

A

placental insufficiency

19
Q

what labs to check with pustular psoriasis of pregancy (aka impetigo herpetiformis)

A

hypocalcemia
elev ESR
leukocytosis

Pregnancy Dermatoses (1 decks)

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